Harmful cyanotoxins: hepatotoxic effects of microcystin in mammalian animals

• Autorzy: Bownik A , Skowronski T.
• Języki publikacji: EN

Abstrakty

EN

Cyanobacterial blooms, often observed in eutrophic water reservoirs, produce toxic metabolites known as cyanotoxins that affect animal health. There are five groups of cyanotoxins classified on the basis of their toxic action: hepatotoxins, neurotoxins, cytotoxins, dermatotoxins and irritant toxins. Microcystin (MC) is a very common and well described hepatotoxin produced by various genera, such as Microcystis, Anabaena, Planktothrix, Anabenopsis, Hapalosiphon and Nostoc. It acts as an inhibitor of serine/threonine protein phosphatase 1 (PP1) and 2A (PP2A), inducing hyperphosphorylation of cell proteins and a variety of toxic changes in hepatocytes often leading to liver insufficiency and death caused by hypovolemic shock. Since the reports on MC toxicity are on the increase this cyanotoxin should be treated as an important environmental factor affecting human and animal health. A brief overview of existing literature on the intake, mechanism of action, and hepatotoxic effects on mammalian animals is presented in this paper

Słowa kluczowe

EN

mammal; animal health; Cyanoprokaryota; bloom; water reservoir; toxic metabolite; production; cyanotoxin; microcystin; hepatotoxic effect

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 05
• Opis fizyczny: p.522-524,ref.

Twórcy

autor

Bownik A

• University of Lublin, 4 Norwida Street, 20-061 Lublin, Poland

autor

Skowronski T.

Bibliografia

• 1.Battle T., Touchard C., Moulsdale H. J., Dowsett B., Stacey G. N.: New cell substrates for in vitro evaluation of microcystin hepato-cytotoxicity. Toxicol. in vitro 1997, 11, 557-567.
• 2.Bell S. G., Codd G. A.: Cyanobacterial toxins and human health. Rev. Med. Microbiol. 1994, 5, 256-264.
• 3.Botes D. P., Wessels P. L., Kruger H., Runnegar M. T. C., Sanitkarn S., Smith R. J., Barna J. C. J., Williams D. H.: Structural studies on cyanoginosins-LR, YR, YA and YM, peptide toxins from Microcystis aeruginosa. J. Chem. Soc., Perkin Trans. 1985, 1, 2311.
• 4.Bouaicha N., Maatouk I.: Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes. Toxicol. Lett. 2004, 148, 53-63.
• 5.Carmichael W. W.: Cyanobacteria secondary metabolites The cyanotoxins. J. Appl. Bacteriol. 1992, 72, 445-459.
• 6.Carmichael W. W.: Diseases related to freshwater blue-green algal toxins and control measures, [in:] Falconer I. (Ed.): Algal Toxins in Seafood and Drinking Water. Academic Press, London 1993, 187-209.
• 7.Carmichael W. W.: The toxins of cyanobacteria. Sci. Am. 1994, 270, 64-70.
• 8.Carmichael W. W. Schwartz L. D.: Preventing livestock deaths from blue- -green algae poisoning. Farm. Bull. 2275, US Dept. of Agriculture; Washington, DC, USA 1984.
• 9.Chong M. W. K., Gu K. D., Lam P. K. S, Yang M., Fong W. F.: Study on the toxicity of microcystin-LR on cultured cells. Chemosphere 2000, 41, 143-147.
• 10.Claeyssens S., Chedeville A., Lavoinne A.: Inhibition of protein phosphatases activates glucose-6-phosphatase in isolated rat hepatocytes. FEBS Lett. 1993, 315, 7-10.
• 11.De Maagd P. G. J., Hendriks A. J., Seinen W., Sijm D. T. H. M.: pH-dependent hydrophobicity of the cyanobacteria toxin microcystin-LR. Water Res. 1999, 33, 677-680.
• 12.Ding W. X., Shen H. M., Ong C. N.: Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 2000, 32, 547-555.
• 13.Eriksson J. E., Toivola D., Meriluoto J. A. O., Karaki H., Han Y., Hartshorne D.: Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases. Biochem. Biophys. Res. Commun. 1990, 173, 1347-1353.
• 14.Falconer I. R., Dornbusch M., Moran G., Yelung S. K.: Effect of cyanobacterial (blue-green algal) toxins from Microcystis aeruginosa on isolated enterocytes from chicken small intestine. Toxicon 1992, 30, 790-793.
• 15.Fladmark K. E., Brustugun O. T., Hovland R., Boe R., Gjertsen B. T., Zhivotovsky B., Doskeland S. O.: Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors. Cell Death Differ. 1999, 6, 1099-1108.
• 16.Frangez R., Kosec M., Sedmak B., Beravs K., Demsar F., Juntes P., Pogacnik M., Suput D.: Subchronic liver injuries caused by microcystins. Pflugers Arch. Eur. J. Physiol. 2000, 440 (Suppl), R103-R104.
• 17.Gupta N., Pant S. C., Vijayaraghavan R., Lakshmana R. P. V.: Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 2003, 188, 285-296.
• 18.Ito E., Kondo F., Terao K., Harada K. I.: Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin- -LR, Toxicon 1997, 35, 1453-1457.
• 19.Lahti K., Rapala J., Färdig M., Niemelä M., Sivonen K.: Persistence of cyanobacterial hepatotoxin, microcystin-LR in particulate material and dissolved in Lake water, Water Res. 1997, 31, 1005-1012.
• 20.Lankoff A., Kołątaj A.: Influence of microcystine-YR and nodularin on the activity of some glucosidases in mouse liver. Toxicology 2000, 146, 177-185.
• 21.Lankoff A., Kołątaj A.: Influence of microcystin and nodularin on the activity of some proteolytic enzymes in mouse liver. Toxicon 2001, 39, 419-423.
• 22.Maatouk I., Bouaicha N., Plessis M. J., Perin F.: Detection by 32P-postlabelling of 8-oxo-7,8-dihydro-2-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver. Mut. Res. 2004, 564, 9-20.
• 23.MacKintosh C., Beattie K. A., Klumpp S., Cohen P., Codd G. A.: Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 1990, 264, 187-192.
• 24.McDermott C. M., Nho W. C., Howard W., Holton B.: The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types. Toxicon 1998, 36, 1981-1996.
• 25.Millward T. A., Zolnierowicz S., Hemmings B. A.: Regulation of protein kinase cascades by protein phosphatase 2A. TIBS 1999, 24, 186-191.
• 26.Robinson N. A., Pace J. G., Matson C. F., Miura G. A., Lawrence W. B.: Tissue distribution, excretion and hepatic biotransformation of microcystin- -LR in mice. J. Pharmacol. Exp. Therap. 1991, 256, 176-182.
• 27.Solter P., Liu Z., Guzman R.: Decreased hepatic ALT synthesis is an outcome of subchronic microcystin-LR toxicity. Toxicol. Appl. Pharmacol. 2000, 164, 216-220.
• 28.Turner P. C., Gammie A. J., Hollinrake K., Codd G. A.: Pneumonia associated with contact with cyanobacteria. Brit. Med. J. 1990, 300, 1440-1441.
• 29.Yoshida T., Makita Y., Nagata S., Tsusumi T., Yoshida F., Sekijima M., Tamura S., Ueno Y.: Acute oral toxicity of microcystin-LR, a potent cyanobacterial hepatotoxin in mice. Nat. Toxins 1997, 5, 91-95.
• 30.Żegura B., Lah T. T., Filipic M.: The role of reactive oxygen species in microcystin-LR-induced DNA damage. Toxicology 2004, 200, 59-68.