DNA adducts in environmental, occupational and life-style studies in human biomonitoring

• Autorzy: Hemminki K. , Grzybowska E. , Widlak P. , Chorazy M.
• Języki publikacji: EN

Abstrakty

EN

The importance of DNA adducts in carcinogenesis has been discussed. The 32P-postlabelling method was developed as a quantitative technique to measure the level of different DNA adducts including adducts in human DNA. The elevated level of DNA adducts was found in white blood cells in persons exposed environmentally and occupationally to high concentrations of PAHs (polycyclic aromatic hydro­carbons) in the ambient air. Tobacco also generated higher level of DNA adducts both in lymphocytes and laryngeal tissues of smokers. Exposure to styrene has been of interest world-wide because of the very high exposure and persistence of adducts in DNA of lamination workers.

Słowa kluczowe

EN

protein importance; occupational exposure; environmental exposure; man; DNA importance; polycyclic aromatic hydrocarbon; P-postlabelling method; carcinogenesis; mutation; biomonitoring; leucocyte

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 2
• Opis fizyczny: p.305-312,fig.

Twórcy

autor

Hemminki K.

• Karolinska Institute, 141 57 Huddinge, Sweden

autor

Grzybowska E.

autor

Widlak P.

autor

Chorazy M.

Bibliografia

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