Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

• Autorzy: Galecka M. , Szachta P. , Bartnicka A. , Lykowska-Szuber L. , Eder P. , Schwiertz A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was evaluation of the correlation between the level of clinical activity of Crohn’s disease (CD) and the number of Faecalibacterium prausnitzii, total number of bacteria and the concentration of selected short chain fatty acids (SCFA) in stool. 34 individuals diagnosed with Crohn’s disease participated in this study in 2011. The disease activity was determined according to the Crohn Disease Activity Index (CDAI). The number of Faecalibacterium prausnitzii and total number of bacteria were monitored by RT-PCR. The concentrations of SCFA were determined by gas chromatography. In CD patients, Faecalibacterium prausnitzii number and percentage of the total number of bacteria were greatly reduced. In patients with CD the percentage of acetate was elevated (70%), while the percentages of propionate and butyrate were significantly reduced (14.9% and 7.99%, respectively).

Słowa kluczowe

EN

Faecalibacterium prausnitzii; Crohn's disease; inflammatory bowel disease; etiopathogenesis; short chain fatty acid

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2013
• Tom: 62
• Numer: 1
• Opis fizyczny: p.91-95,ref.

Twórcy

autor

Galecka M.

• Institute of Microecology, Sielska 10, 60-129 Poznan, Poland

autor

Szachta P.

• Institute of Microecology, Sielska 10, 60-129 Poznan, Poland

autor

Bartnicka A.

• Institute of Microecology, Sielska 10, 60-129 Poznan, Poland

autor

Lykowska-Szuber L.

• Department of Gastroenterology, Human Nutrition and Internal Diseases, University of Medical Sciences in Poznan, Poznan, Poland

autor

Eder P.

• Department of Gastroenterology, Human Nutrition and Internal Diseases, University of Medical Sciences in Poznan, Poznan, Poland

autor

Schwiertz A.

• Institute of Microecology, 8 Auf den Lueppen, Herborn, Germany

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