Evaluation of antiepileptic activity of methanolic leaves extract of Tragia involucrata Linn. in mice

• Autorzy: Varma G. G. , Mathai B. K. , Das K. , Gowda G. , Rammohan S. , Einstein J. W.
• Języki publikacji: EN

Abstrakty

EN

The present investigation was aimed to study an antiepileptic activity of methanolic extract of Tragia involucrata Linn in mice. In vivo screening models like maximal electroshock-induced convulsion (MES), pentylenetetrazole (PTZ) and picrotoxin (PTX) induced models are used to evaluate the antiepileptic effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the MES induced convulsion, methanolic extract of Tragia involucrata (METI) at high dose (800 mg/kg body weight), showed high significant inhibition on tonic hind limb extension (THLE, 6.83 ±0.30***) and decrease in duration of stupor period (108.7 ±6.53***). In PTZ and PTX induced model METI (400 mg/kg and 800 mg/kg) showed significant delay on the onset of convulsions, decreased duration of convulsion and reduced mortality significantly. It also showed significant decrease in brain MDA level in lipid peroxidation profile, and increase in the brain glutathione levels in mice against PTZ induced convulsion. The results confirmed that Tragia involucrata Linn possesses dose dependent antiepileptic activity.

Słowa kluczowe

EN

antiepileptic drug; antiepileptic activity; methanolic extract; leaf; plant extract; Tragia involucrata; Indian stinging nettle; mice; mouse; anticonvulsant action; pentylenetetrazol; picrotoxin

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2014
• Tom: 12
• Numer: 2
• Opis fizyczny: p.167-179,fig.,ref.

Twórcy

autor

Varma G. G.

• Department of Pharmacology and Toxicology, St.John’s Pharmacy College, II Main, R.P.C Lay out, Bangalore, Karnataka, India

autor

Mathai B. K.

• Department of Pharmacology and Toxicology, St.John’s Pharmacy College, II Main, R.P.C Lay out, Bangalore, Karnataka, India

autor

Das K.

• Department of Pharmacognosy and Phytochemistry, Krupanidhi College of Pharmacy, Carmelaram Post, Varthur Hobli, Bangalore, Karnataka, India

autor

Gowda G.

• Department of Pharmacology and Toxicology, St.John’s Pharmacy College, II Main, R.P.C Lay out, Bangalore, Karnataka, India

autor

Rammohan S.

• Department of Pharmacology and Toxicology, St.John’s Pharmacy College, II Main, R.P.C Lay out, Bangalore, Karnataka, India

autor

Einstein J. W.

• Department of Pharmacology and Toxicology, St.John’s Pharmacy College, II Main, R.P.C Lay out, Bangalore, Karnataka, India

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