Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

• Autorzy: Deveci B. , Ayna B. , Tacir I.H. , Deveci E. , Tuncer M.C. , Pala A.
• Języki publikacji: EN

Abstrakty

EN

Background: Nicotine is associated with increased incidence of periodontal disease and poor response to therapy. This article aimed at identifying the expression of matrix metalloproteinases 2 (MMPs2) and vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. Materials and methods: In this experimental study, rats were divided into nicotine and control groups. While the rats in the nicotine group (n = 6) were administered 2 mg/kg nicotine sulphate for 28 days, the animals in the control group (n = 6) were only administered 1.5 mL physiologic saline solution subcutaneously for 28 days. Results: Histological sections were prepared and immunohistochemically stained for MMP2 and VEGF. The sections stained with Trichrome-Masson were observed under light microscope. VEGF and MMP2 immunoreactivity of periodontal gingiva and dentin was assessed by immunohistochemical staining. Conclusions: Nicotine reduces MMP production, disrupts collagen synthesis and causes periodontitis. We observed that nicotine increases periodontitis by disrupting periodontal membrane and prevents tooth to anchor in dental alveoli by disrupting epithelial structure. (Folia Morphol 2018; 77, 3: 471–477)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2018
• Tom: 77
• Numer: 3
• Opis fizyczny: p.471–477,fig.,ref.

Twórcy

autor

Deveci B.

• Department of Periodontology, Faculty of Dentistry, University of Dicle, Diyarbakir, Turkey

autor

Ayna B.

• Department of Paediatric Dentistry, Faculty of Dentistry, University of Dicle, Diyarbakir, Turkey

autor

Tacir I.H.

• Department of Prosthodontics, Faculty of Dentistry, University of Dicle, Diyarbakir, Turkey

autor

Deveci E.

• Department of Histology and Embryology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey

autor

Tuncer M.C.

• Department of Anatomy, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey

autor

Pala A.

• Department of Histology and Embryology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey

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Identyfikatory

DOI

10.5603/FM.a2018.0004