Aberrant changes of somatostatin and neuropeptide Y in brain of a genetic rat model for epilepsy: tremor rat

• Autorzy: Xu X. , Guo F. , Cai X. , Yang J. , Zhao J. , Min D. , Hao L. , Cai J.
• Języki publikacji: EN

Abstrakty

EN

Excessive excitation or loss of inhibitory neurotransmission has been closely related to epileptic activity. Somatostatin (SST) and Neuropeptide Y (NPY) are members of endogenous neuropeptides which are recognized as important modulator of classical neurotransmitter, distributed abundantly in mammalian central nervous system. Abnormal expression of these two neuropeptides evidenced in some epileptic models highlights the relevance of SST or NPY in the pathogenesis of epilepsy. The tremor rat (TRM) is a genetic epileptic animal model which can manifest tonic convulsions without any external stimuli. The present study aimed to investigate the distribution and expression of SST and NPY in TRM brains, including hippocampus, temporal lobe cortex and cerebellum. Our RT‑PCR data showed that up‑regulated mRNA expression of SST and NPY was discovered in TRM hippocampus and temporal lobe cortex compared with control (Wistar) rats. The peptide levels of these neuropeptides in brain areas mentioned above were both apparently higher than that in normal Wistar rats as well. However, in cerebellums, neither SST nor NPY was significantly changed compared with control group. The immunohistochemical data showed that SST and NPY were widely present throughout CA1, CA3 and the hilus of hippocampus, the entorhinal cortex of temporal lobe cortex, as well as cerebellar Purkinje layer. In conclusion, our results discovered the aberrant changes of SST and NPY in several TRM brain regions, suggesting that the peptidergic system might be involved in TRM epileptiform activity.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2016
• Tom: 76
• Numer: 3
• Opis fizyczny: p.165-175,fig.,ref.

Twórcy

autor

Xu X.

• Department of Neurology, First Hospital of China Medical University, Shenyang, China
• Institute of Neurology, China Medical University, Shenyang, China

autor

Guo F.

• Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, Shenyang, China

autor

Cai X.

• Central Lab, the First Hospital of China Medical University, Shenyang, China

autor

Yang J.

• Department of Neurology, First Hospital of China Medical University, Shenyang, China
• Institute of Neurology, China Medical University, Shenyang, China

autor

Zhao J.

• Department of Neurology, First Hospital of China Medical University, Shenyang, China
• Institute of Neurology, China Medical University, Shenyang, China

autor

Min D.

• Experiment Center of Traditional Chinese Medicine, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, China

autor

Hao L.

• Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, Shenyang, China

autor

Cai J.

• Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, Shenyang, China

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