New gene responsible for resistance of clinical corynebacteria to macrolide, lincosamide and streptogramin B

• Autorzy: Szemraj M. , Kwaszewska A. , Szewczyk E.M.
• Języki publikacji: EN

Abstrakty

EN

The subject of the study was phenotypic marking of the antibiotic susceptibility and MLSB resistance mechanism in Corynebacterium spp. isolated from human skin (18 isolates) and from clinical materials (19 isolates). The strains were tested for the presence of the erm(A), erm(B), erm(C), erm(X), lnu(A), msr(A), msr(B) and mph(C) genes. Clinical isolates showed wide resistance to antibiotics. In 89% clinical isolates and 72% skin microbiota a constitutive type of MLSB resistance was found. In 12 clinical isolates the erm(C) gene was detected-eight of which had erm(X) as well as erm(C), two harboured erm(X), erm(C) and erm(A) and two demonstrated only erm(C).

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2018
• Tom: 67
• Numer: 2
• Opis fizyczny: p.237-240,fig.,ref.

Twórcy

autor

Szemraj M.

• Department of Pharmaceutical Microbiology and Microbiological Diagnostics, Medical University of Lodz, Lodz, Poland

autor

Kwaszewska A.

• Institute of Health Sciences, State College of Applied Sciences in Skierniewice, Skierniewice, Poland

autor

Szewczyk E.M.

• Department of Pharmaceutical Microbiology and Microbiological Diagnostics, Medical University of Lodz, Lodz, Poland

Bibliografia

• Akan A., J. Bengisun, A. Bati, M. Arat, O. Ilhan and H. Akan. 2002. A case of catheter related septicemia caused by Corynebacterium jeikeium. Turk. J. Haematol. 19: 47–50.
• Alibi S., A. Ferjani, J. Boukadida, M.E. Cano, M. Fernández-Martínez, L. Martínez-Belmares J., S. Detterline, J.B. Pak and J.P. Parada. 2007. Corynebacterium endocarditis species – specific risk factors and outcomes. BMC Infect. Dis. 7: 4.
• Cetin E.S., H. Gunes, S. Kaya, B.C. Aridogan and M. Demirci. 2010. Distribution of genes encoding resistance to macrolides, lincosamides and streptogramins among clinical staphylococcal isolates in a Turkish University Hospital. J. Microbiol. Immunol. Infect. 43: 524–529.
• Chaieb K., T. Zmantar, O. Chehab, O. Bouchami, A.B. Hasen and K. Mahdouani. 2007. Antibiotic resistance genes detected by multiplex PCR assays in Staphylococcus epidermidis strains isolated from dialysis fluid and needles in a dialysis service. Jpn. J. Infect. Dis. 60: 183–187.
• Chen F.L., P.R. Hsueh, S.O. Teng, T.Y. Ou, W.S. Lee 2012. Corynebacterium striatum bacteremia associated with central venous catheter infection. J. Microbiol. Immunol. Infect. 45: 255–258.
• CLSI, Clinical and Laboratory Standards Institute. 2015. Methods for Antimicrobial Dilution and Disk Susceptibility Testing ofInfrequently Isolated or Fastidious Bacteria; Approved Guideline– 3nd ed. M45, Wayne, PA, USA.
• Daisuke U., T. Oishi, K. Yamane and K. Terada. 2017. Corynebacterium striatum bacteremia associated with a catheter-related blood stream infection. 2017. Case Rep. Infect. Dis. 2017: 2682149.
• El-Mahdy T.S., S. Abdalla, R. El-Domany, M.S. Mohamed,J.I. Ross and A.M. Snelling. 2010. Detection of a new erm(X)-mediated antibiotic resistance in Egyptian cutaneous propionibacteria. Anaerobe 16: 376–379.
• EUCAST, European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 7.1, valid from 2017.03.13.
• Gatermann S.G., T. Koschinski and S. Friedrich. 2007. Distribution and expression of macrolide resistance genes in coagulase-negative staphylococci. Clin. Microbiol. Infect. 13: 777–781.
• Hahn W. O., J. B. Werth, S. M. Butler-Wu and R. M. Rakita. 2016. Multidrug-resistant Corynebacterium striatum associated with increased use of parenteral antimicrobial drugs. Emerg. Infect. Dis. 22: 1908–1914.
• Juda M. 2010. PhD. thesis, Phenotypic and genetic analysis of coagulase-negative staphylococci resistance to macrolides, lincosamides and streptogramins (in Polish). Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Medical University of Lublin. Lublin. Poland.
• Khamis A., D. Raoult and B. La Scola. 2004. rpoB gene sequencing for identification of Corynebacterium species. J. Clin. Microbiol. 42: 3925–3931.
• Lee P.P., D.A. Ferguson and F.A. Sarubbi. 2005. Corynebacterium striatum: an underappreciated community and nosocomial pathogen. J. Infect. 50: 338–343.
• Lina G., A. Quaglia, M. Reverdy, R. Leclercq, F. Vandenesch, and J. Etienne. 1999. Distribution of genes encoding resistance to macrolides, lincosamides and streptogramins among staphylococci. Antimicrob. Agents Chemother. 43: 1062–1066.
• Luna V.A., P. Coates, A. Eady, J.H Cove., T.T.H. Nguyen and M.C. Roberts. 1999. A variety of Gram-positive bacteria carry mobile mef genes. J. Antimicrob. Chemother. 44: 19–25
• Maravic G. 2004. Macrolide resistance based on the Ermmediated rRNA methylation. Curr. Drug Targets Infect. Disord. 4: 193–202.
• Mookadam F., M. Cikes, L.M. Baddour, I.M. Tleyjeh and M. Mookadam. 2006. Corynebacterium jeikeium endocarditis: a systematic overview spanning four decades. Eur. J. Clin. Microbiol. Infect. Dis. 25: 349–353.
• Morata L., E. Tornero, J.C. Martínez-Pastor, S. García-Ramiro, J. Mensa and A. Soriano. 2014. Clinical experience with linezolid for the treatment of orthopaedic implant infections. J. Antimicrob. Chemother. 69: 47–52.
• Ojo K.K., M.J. Striplin, C.C. Ulep, N.S. Close, J. Zittle, H. Luis, J. Leitao, M.C. Roberts and M. Bernardo. 2006. Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates. Antimicrob. Agents Chemother. 50: 1089–1091.
• Olender A. 2013. Antibiotic resistance and detection of the most common mechanism of resistance (MLSB) of opportunistic Corynebacterium. Chemotherapy 59: 294–306
• Olender A. and M. Niemcewicz. 2010. Macrolide, lincosamide, and streptogramin B-constitutive-type resistance in Corynebacterium pseudodiphtheriticum isolated from upper respiratory tract specimens. Microb. Drug Resist. 16: 119–122.
• Ortiz-Perez A., N.Z. Martin-de-Hijas, J. Esteban, M.I. Fernandez-Natal, J.I. Garcia-Cia and R. Fernandez-Roblas. 2010. High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb. Drug Resist. 16: 273–277.
• Otsuka Y., K. Ohkusu, Y. Kawamura, S. Baba, T. Azeki and S. Kimura. 2006. Emergence of multidrugresistant Corynebacterium striatum as a nosocomial pathogen in long-term hospitalized patients with underlying diseases. Diagn. Microbiol. Infect. Dis. 54: 109–114.
• Perreten V., L. Vorlet-Fawer, P. Slickers, R. Ehricht, P. Kuhnert, and J. Frey. 2005. Microarray-based detection of 90 antibiotic resistance genes of gram-positive bacteria. J. Clin. Microbiol. 43: 2291–2302.
• Reddy B.S., A. Chaudhury, U. Kalawat, R. Jayaprada, G.S.K. Reddyand B.V. Ramana. 2012. Isolation, speciation and antibiogram of clinically relevant non-diphterial Corynebacteria (Diphtheroids). Indian J. Med. Microbiol. 30: 52–57.
• Roberts M.C. 2008. Update on macrolide-lincosamide streptogramin, ketolide, and oxazolidinone resistance genes. FEMS Microbiol. Lett. 282: 147–159.
• Roberts M.C., R.B. Leonard, A. Briselden, F.D. Schoenknecht and M.B. Coyle. 1992. Characterization of antibiotic-resistant Corynebacterium striatum strains. J. Antimicrob. Chemother. 30: 463–474.
• Roberts M.C., J. Sutcliffe, P. Courvalin, L.B. Jensen, J. Rood, and H. Seppala. 1999. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob. Agents Chemother. 43: 2823–2830.
• Rosato A.E., B.S. Lee and K.A. Nash. 2001. Inducible macrolide resistance in Corynebacterium jeikeium. Antimicrob. Agents Chemother. 45: 1982–1989.
• Ross J.I., A.A. Eady, E. Carnegle and J.H. Cove. 2002. Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneus propionibacterie from six European cities. J. Antimicrob. Chemother. 49: 165–168.
• Soriano F., J. Zapardiel and E. Nieto. 1995. Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents. Antimicrob. Agents Chemother. 39: 208–214.
• Sutcliffe J., T. Grebe, A. Tait-Kamradt, and L. Wondrack. 1996. Detection of erythromycin-resistant determinants by PCR. Antimicrob. Agents Chemother. 40: 2562–2566.
• Szemraj M, A. Kwaszewska, R. Pawlak and E.M. Szewczyk. 2014. Macrolide, lincosamide, and streptogramin B resistance in lipophilic corynebacteria inhabiting healthy human skin. Microb. Drug Resist. 20: 404–409.
• Tang S., L. Yao, X. Hao, X. Zhang, G. Liu, X. Liu, M. Wu, L. Zen, H. Sun, Y. Liu and others. 2015. Efficacy, safety and tolerability of linezolid for the treatment of XDR-TB: a study in China. Eur. Respir. J. 45: 161–170.
• Tauch A., N. Bischoff, I. Brune and J. Kalinowski. 2003. Insights into the genetic organization of the Corynebacterium diphtheriae erythromycin resistance plasmid pNG2 deduced from its complete nucleotide sequence. Plasmid. 49: 63–74.
• Tauch A., O. Kaiser, T. Hain, A. Goesmann, B. Weisshaar,A. Albersmeier, T. Bekel, N. Bischoff, I. Brune, T. Chakraborty and others. 2005. Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipidrequiring bacterium of the human skin flora. J. Bacteriol. 187: 4671–4682.
• Tauch A., F. Kassing, J. Kalinowski and A. Pühler. 1995. The Corynebacterium xerosis composite transposon Tn5432 consists of two identical insertion sequences, designated IS1249, flanking the erythromycin resistance gene ermCX. Plasmid 34: 119–131.
• Tleyjeh I.M., M.O. Qutub, M. Bakleh, M.R. Sohail and A. Virk. 2005. Corynebacterium jeikeium prosthetic joint infection: case report and literature review. Scand. J. Infect. Dis. 37: 151–153.
• Wang C., D. Mattson and A. Wald. 2001. Corynebacterium jeikeium bacteriemia in bone marrow transplant patients with Hickmancatheters. Bone Marrow Transplant 27: 445–449.
• Weisblum B. 1995. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39: 577–585.

Identyfikatory

DOI

10.21307/pjm-2018-028