DTI U-fibre track density quantification localises epileptogenic zone in cryptogenic focal epilepsy

• Autorzy: Goc J. , Hartl E. , Noachtar S. , Vollmar C.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: Pharmacoresistant focal epilepsy might be treated surgically by removing the seizure onset zone. However, in cryptogenic epilepsy no structural lesion is visible in clinical MRI, challenging the exact diagnosis and planning of resective surgery. Here, we present a new DTI analysis approach based on quantification of track density images of short‑association fibers, called U‑fibers. This approach identifies previously undetected structural abnormalities. AIM(S): The aim of this study was to develop a new approach that localizes the epileptogenic zone in patients with cryptogenic focal epilepsy. METHOD(S): Diffusion Tensor Imaging (DTI) data was acquired for 23 patients with cryptogenic focal epilepsy and 31 healthy participants on a GE Signa HDx 3T Scanner with 64 diffusion weighted directions, a b-value of 1000 s/mm² and 2.4 mm slice thickness. Whole brain streamline tracking was performed and the population of U-fibre tracks was selected from which fibre density maps were created. These density maps were spatially normalized to a common space. Statistical comparison to a population of healthy controls was carried out to identify clusters of reduced fibre density in individual patients. RESULTS: The quantification of U-fiber track density images resulted in clusters of reduced fiber density, which might reflect the microstructural changes in the vicinity of the epileptogenic zone (EZ). This approach correctly identified the EZ in 86% of patients with specificity of 83%. CONCLUSIONS: Quantification of U‑fiber track density images localizes the EZ in cFE, with higher sensitivity and specificity than previously reported studies. This approach can improve the surgical planning of the electrode implantation, necessary for in cFE patients. FINANCIAL SUPPORT: This study was supported by the Friedrich-Baur-Stiftung and the Herta-Riehr Stiftung.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.74

Twórcy

autor

Goc J.

• Deptament of Neurology, Epilepsy Centre, University of Munich Hospital, Munich, Germany

autor

Hartl E.

• Deptament of Neurology, Epilepsy Centre, University of Munich Hospital, Munich, Germany

autor

Noachtar S.

• Deptament of Neurology, Epilepsy Centre, University of Munich Hospital, Munich, Germany

autor

Vollmar C.

• Deptament of Neurology, Epilepsy Centre, University of Munich Hospital, Munich, Germany