In vitro evaluation of albendazole nanocrystals against Echinococcus granulosus protoscolices

• Autorzy: Fateh R. , Norouzi R. , Mirzaei E. , Nissapatron V. , Nawaz M. , Khalifeh-Gholi M. , Hamta A. , Adnani Sadati S.J. , Siyadatpanah A. , Fattahi Bafghi A.
• Języki publikacji: EN

Abstrakty

EN

Echinococcus granulosus is a zoonotic parasite causing hydatidosis in humans and animals. This study has been done in order to investigate the effect of albendazole nanocrystals on the viability of E. granulosus protoscolices. The average size and hydrodynamic diameter of albendazole nanocrystals were 976±218 and 1334±502 nm, respectively. Fertile hydatid cysts were isolated from the liver of slaughtered sheep. The isolated cysts were further identified using morphological and molecular techniques. The nucleotide sequence analysis indicated that the genotype of the protoscolices was E. granulosus sensu stricto with 100% similarity. The parasites were examined precisely for susceptibility to albendazole nanocrystals. The results revealed that albendazole nanocrystals are effective in removing protoscolices. It was observed that 1 μg/ml albendazole nanocrystals and albendazole completely inhibited the viability of the protoscolices within 17 and 23 days, respectively. The results suggested that albendazole nanocrystals can be used as an alternative effective treatment for E. granulosus infection.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2021
• Tom: 67
• Numer: 2
• Opis fizyczny: p.203-212,fig.,ref.

Twórcy

autor

Fateh R.

• Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
• Department of Microbiology and Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran

autor

Norouzi R.

• Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

autor

Mirzaei E.

• Department of Medical Nanotechnology, Shiraz University of Medical Sciences, Shiraz, Iran

autor

Nissapatron V.

• School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team) and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat, Thailand

autor

Nawaz M.

• Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi Arabia

autor

Khalifeh-Gholi M.

• Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
• Department of Microbiology and Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran

autor

Hamta A.

• Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran

autor

Adnani Sadati S.J.

• Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
• Department of Microbiology and Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran

autor

Siyadatpanah A.

• Ferdows Paramedical School, Birjand University of Medical Sciences, Birjand, Iran

autor

Fattahi Bafghi A.

• Department Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Identyfikatory

DOI

10.17420/ap6702.330