Oxidative stress and inflammatory response in rat brain and live R following oral administration of silver nanoparticles

• Autorzy: Skalska J. , Frontczak-Baniewicz M. , Lenkiewicz A. , Struzynska L.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: Silver nanoparticles (AgNPs) are one of the most important class of nanomaterials used in a wide range of medical and industrial applications. However, the information about their toxicity to mammalsislimited. The aim of thisstudy was to investigate the effect of oral exposure to AgNPs on brain and liver of rats. The deposition of silver nanoparticles in these organs has been shown to induce hepatotoxicity and neurotoxicity. These toxic effects may include oxidative stress with subsequent inflammatory response. METHODS: Wistar rats were exposed orally to AgNPs (10±4 nm in diameter) or silver ions at a dose of 0.2 mg AgNPs or Ag+/ kg bw for 14 days. Then all animals were sacrificed 24 h after last exposure and tissues were collected for further studies. RESULTS: The presence of AgNPs in brain tissue was confirmed by using TEM technique. The level of free radicals and end-products of lipid peroxidation increased in both organs after exposure to both, silver nanoparticles or silver ions. However, the changes in inflammatory markers (based on IL-1β, IL-6 and TNF-α relative protein levels) were not statistically significant. CONCLUSIONS: These results show that following AgNPs or silver ions administration, oxidative stress is induced in brain and liver tissues. However, it seems that the time of exposure to both of silver forms was too short to cause the inflammatory response.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S100

Twórcy

autor

Skalska J.

• Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Frontczak-Baniewicz M.

• Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Lenkiewicz A.

• Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Struzynska L.

• Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland