The effect of adenosinergic system on development of sensitization to morphine-induced withdrawal signs in rats

• Autorzy: Listos J. , Talarek S. , Orzelska J. , Fidecka S.
• Języki publikacji: EN

Abstrakty

EN

In the presented study the effect of continuous and sporadic treatment with morphine (MPH) on the severity of MPH withdrawal signs was examined in rats. Also, the effect of A1 and A2A adenosine agonists (N6-cyclopentyladenosine and 2-p-(2-carboxyethyl) phenethylamino5’-N- ethylcarboxamidoadenosine hydrochloride, respectively) on development of this sensitization was studied. Rats were treated with increasing doses of MPH and were divided into groups. First group received MPH for 8 consecutive days (continuous group), the second, received MPH in four two-day periods with three 36-hour breaks (sporadic group). Control group received saline. Adenosine drugs were administered during three MPH-free periods (6 injections). Last day, to induce withdrawal signs, 1 hour after MPH injection, naloxon was administered. The number of jumps was recorded for a period of 30 min. Jumps were significantly greater in sporadic group in compare with continuous group, which confirm that sensitization to MPHinduced withdrawal signs has been developed. There were not any jumps in control rats. Rats showed that stimulation of A2A receptors inhibited the withdrawal signs. Less significant effect was observed after stimulation of A1 receptors. The findings showed that repeated withdrawal episodes intensified the severity of withdrawal signs and adenosinergic system, mainly by A2A receptors, was able to inhibit the development sensitization to MPH withdrawal signs.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.361

Twórcy

autor

Listos J.

• Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland

autor

Talarek S.

• Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland

autor

Orzelska J.

• Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland

autor

Fidecka S.

• Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland