Virulence of geographically different Cryptosporidium parvum isolates in experimental animal model

• Autorzy: Sayed F.G. , Hamza A.I. , Galal L.A. , Sayed D.M. , Gaber M.
• Języki publikacji: EN

Abstrakty

EN

Cryptosporidium parvum is a coccidian parasite which causes gastrointestinal disease in humans and a variety of other mammalian species. Several studies have reported different degrees of pathogenicity and virulence among Cryptosporidium species and isolates of the same species as well as evidence of variation in host susceptibility to infection. The study aimed to investigate infectivity and virulence of two Cryptosporidium parvum “Iowa isolate” (CpI) and a “local water isolate” (CpW).Thirty-three Swiss albino mice have been divided into three groups: Negative control Group (C), the CpI group infected with “Iowa isolate “and the CpW group infected with C. parvum oocysts isolated from a local water supply. Infectivity and virulence have been measured by evaluating clinical, parasitological and histological aspects of infection. Significant differences were detected regarding oocysts shedding rate, clinical outcomes, and the histopathological picture of the intestine, lung, and brain. It was concluded that the local water isolate is significantly more virulent than the exported one.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2016
• Tom: 62
• Numer: 3
• Opis fizyczny: p.221–232,fig.,ref.

Twórcy

autor

Sayed F.G.

• Department of Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

autor

Hamza A.I.

• Department of Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

autor

Galal L.A.

• Department of Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

autor

Sayed D.M.

• Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71515, Egypt

autor

Gaber M.

• Department of Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

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Identyfikatory

DOI

10.17420/ap6203.56