Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system

• Autorzy: Janicki P.K. , Seibold G. , Siembab D. , Paulo E.A. , Szreniawski Z.
• Języki publikacji: EN

Abstrakty

EN

Janicki, P. K., Seibold, G., Siembab, D., Paulo, E. A., and Szreniawski, Z.: Computer assisted quantitative densitometric analysis of ¹²⁵ I-apamin binding sites in the central nervous system. Acta physiol, pol., 1989, 40 (2): 240-249. The binding sites for ¹²⁵ I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, Chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactoTy system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 2
• Opis fizyczny: p.240-249,fig.,ref.

Twórcy

autor

Janicki P.K.

• Department of Pharmacology, Institute of Physiological Sciences, School of Medicine, Warsaw, Poland

autor

Seibold G.

• Strahlenzentrum der Justus-Liebieg-Universitat, Giessen, Germany

autor

Siembab D.

• Department of Pharmacology, Institute of Physiological Sciences, School of Medicine, Warsaw, Poland

autor

Paulo E.A.

• Department of Pharmacology, Institute of Physiological Sciences, School of Medicine, Warsaw, Poland

autor

Szreniawski Z.

• Department of Pharmacology, Institute of Physiological Sciences, School of Medicine, Warsaw, Poland

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