Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs

• Autorzy: Nam A. , Kim S.M. , Jeong J.W. , Song K.H. , Koo T.S. , Seo K.W.
• Języki publikacji: EN

Abstrakty

EN

This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m². The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2017
• Tom: 20
• Numer: 3
• Opis fizyczny: p.611-613,fig.,ref.

Twórcy

autor

Nam A.

• Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea

autor

Kim S.M.

• Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea

autor

Jeong J.W.

• Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea

autor

Song K.H.

• Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea

autor

Koo T.S.

• Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea

autor

Seo K.W.

• Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea

Bibliografia

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Identyfikatory

DOI

10.1515/pjvs-2017-0076