Effects of polyphenols on cell viability of selected varieties of grapes berries and pomace

• Autorzy: Capakova Z. , Humpolicek P. , Mlcek I.
• Języki publikacji: EN

Abstrakty

EN

The effect on cell viability and content of PhC of three grapes varieties – Moravian Muscat, Blue Burgundy and Lemberger is presented. The effect of polyphenols from wine and grapes was studied for many times, but the effect of pomace, the by-product of wine production, was neglected. Thus study is devoted to compare the effect of berries and pomace on cell viability in context of their utilization as source of bioactive compounds. Effect on viability of human keratinocytes (HaCaT) was investigated in vitro using following concentrations of PhC in cultivation medium: 25, 50, 75 and 100 µg·ml–1. The results show that the content of PhC in berries and pomace was similar and the cell viability decreased with increasing concentrations of PhC, in most cases. The impact on cell viability also depends on individual variety of grapes.

Słowa kluczowe

EN

Czech Republic; plant cultivation; grape-vine; Vitis vinifera; fruit bush; grape; grape pomace; Moravian Muscat cultivar; Blue Burgundy cultivar; Lemberger cultivar; cell viability; polyphenol; phenolic compound; proliferation

• Wydawca: -
• Czasopismo: Acta Scientiarum Polonorum. Hortorum Cultus
• Rocznik: 2018
• Tom: 17
• Numer: 2
• Opis fizyczny: p.115-121,ref.

Twórcy

autor

Capakova Z.

• Centre of Polymer Systems, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic

autor

Humpolicek P.

• Centre of Polymer Systems, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic

autor

Mlcek I.

• Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 275, 760 01 Zlin, Czech Republic

Bibliografia

• Ali, A., Hoeflich, K.P., Woodgett, J.R. (2001). Glycogen synthase kinase-3: properties, functions, and regulation. Chem. Rev., 101, 2527–2540.
• Bonfili, L., Cecarini, V., Amici, M., Cuccioloni, M., Angeletti, M., Keller, J.N., Eleuteri, A.M. (2008). Natural polyphenols as proteasome modulators and their role as anti-cancer compounds. FEBS J., 275, 5512–5526.
• Boukamp, P., Petrussevska, R., Breitkreutz, D., Hornung, J., Markham, A. (1988). Normal keratinization in a spontaneously immortalized aneuploid keratinocyte cell line. J. Cell Biol., 106, 761–771.
• de la Cerda-Carrasco, A., López-Solís, R., Nuñez-Kalasic, H., Peña-Neira, A., Obreque-Slier, E. (2014). Phenolic composition and antioxidant capacity of pomaces from four grape varieties (Vitis vinifera L.). J. Sci. Food Agric. [in press]
• Di Lecce, G., Arranz, S., Jáuregui, O., Tresserra-Rimbau, A., Quifer-Rada, P., Lamuela-Raventós, R.M. (2014). Phenolic profiling of the skin, pulp and seeds of Albariño grapes using hybrid quadrupole time-of-flight and triple-quadrupole mass spectrometry. Food Chem., 145, pp. 874–882.
• Gatek, J., Vrana, D., Lukesova, L., Pospiskova, M., Vazan, P., Melichar, B. (2013). Significance of resection margin as a risk factor for local control of early stage breast cancer. Biomed. Pap-Olomouc, 157, 209–213.
• Han, X., Shen, T., Lou, H. (2007). Dietary polyphenols and their biological significance. Int. J. Mol. Sci., 8, 950–988.
• Hakimuddin, F., Tiwari, K., Oaliyath, G., Meckling, K. (2008). Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts. Nutr. Res., 28, 702–713.
• Iacopini, P., Baldi, M., Storchi, P., Sebastiani, L. (2008). Catechin, epicatechin, quercetin, rutin and resveratrol in red grape: Content, in vitro antioxidant activity and interactions. J. Food Compos. Anal., 21, 589–598.
• Jope, R.S., Johnson, G.V. (2004). The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci., 29, 95–102.
• Jurikova, T., Sochor, J., Rop, O., Mlček, J., Balla, S., Szekeres, L., Žitný, R., Zitka, O., Adam, V., Kizek, R. (2012). Evaluation of polyphenolic profile and nutritional value of non-traditional fruit species in the Czech Republic – A comparative study. Molecules, 17, 8968–8981.
• Kang, N.J., Shin, S.H., Lee, H.J., Lee, K.W. (2011). Polyphenols as small molecular inhibitors of signalling cascades in carcinogenesis. Pharm. Therap., 130, 310–324.
• Kucekova, Z., Mlcek, J., Humpolicek, P., Rop, O., Valasek, P., Saha, P. (2011). Phenolic compounds contained in Allium schoenoprasum, Tragopogon pratensis and Rumex acetosa and their antiproliferative effect. Molecules, 16, 9207–9217.
• Lambert, J.D., Hong, J., Yang, G.Y., Liao, J., Yang, C.S. (2005). Inhibition of carcinogenesis by polyphenols, evidence from laboratory investigations. Am. J. Clin. Nutr., 81, 284–291.
• Lu, Y., Jiang, F., Jiang, H., Wu, K., Zheng, X., Cai, Y., Katakowski, M., Chopp, M., To, S.S. (2010). Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. Eur. J. Pharm., 641, 102–107.
• Mandel, S., Youdim, M.B. (2004). Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative disease. Free Radic. Bio. Med., 37, 304–317.
• Mosmann, T. (1973). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 53–63.
• Mustafi, S.B., Chakraborty, P.K., Raha, S. (2010). Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70. PLoS One, 5, e8719, https://doi.org/10.1371/journal.pone.0008719
• Neto, C.C. (2007). Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol. Nutr. Food Res., 51, 652–664.
• Patel, R., Ingle, A., Maru, G.B. (2008). Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/β-catenin pathway. Toxicol. Appl. Pharmacol., 227, 136–146.
• Poolman, T.M., Ng, L.L., Farmer, P.B., Manson, M.M. (2005). Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signalling. Free Radic. Bio. Med., 39, 118–132.
• Rockenbach, I.I., Rodrigues, E., Gonzaga, L.V., Caliari, V., Genovese, M.I., Gonalves, A.E.D.S.S., Fett, R. (2011). Phenolic compounds content and antioxidant activity in pomace from selected red grapes (Vitis vinifera L. and Vitis labrusca L.) widely produced in Brazil. Food Chem., 127, 174–179.
• Rodríguez-Bernaldo de Quirós, A., Lage-Yusty, M.A., López-Hernández, J. (2010). Determination of phenolic compounds in macroalgae for human consumption. Food Chem., 121, 634–638.
• Roy, P., Kalra, N., Prasad, S., George, J., Shukla, Y. (2008). Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signalling pathways. Pharm. Res., 26, 211–217.
• Sharif, T., Auger, C., Alhosin, M., Ebel, C., Achour, M., Étienne-Selloum, N., Fuhrmann, G., Bronner, C., Schini-Kerth, V.B. (2010). Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redoxsensitive up-regulation of p73 and down-regulation of UHRF1. Eur. J. Cancer, 46, 983–994.
• Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J. (2015). Bioactive compounds and antioxidant activity in different types of berries. Int. J. Mol. Sci., 16, 24673-24706.
• Soleas, G.J., Diamandis, E.P., Goldberg, D.M. (1997). Wine as a biological fluid: history, production, and role in disease prevention. J. Clin. Lab. Anal., 11, 287–313.
• Yang, C.S., Landau, J.M., Huang, M.T., Newmark, H.L. (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr., 21, 381–406.
• Zinov’eva, V.N., Spasov, A.A. (2011). Mechanisms of the anticancer effects of plant polyphenols. I. Blockade of initiation of carcinogenesis. Biochemistry (Moscow), Suppl., Ser. B Biomed. Chem., 5, 113–123.

Identyfikatory

DOI

10.24326/asphc.2018.2.10