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2015 | 59 | 2 |

Tytuł artykułu

Curative effect of TFX-Jelfa supplementation on the skin of ovariectomised rats – morphological study

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to assess the effect of thymus factor X (TFX-Jelfa) treatment in hypoestrogenic female rats for the purpose of decreasing skin impairments. Ovariectomised rats were used as a model. The histopathological analysis of the skin after TFX-Jelfa treatment demonstrated that the epidermis was thicker and more desquamated, without deep wrinkles or hypersecretion in comparison to the skin of animals only castrated and not treated with TFX-Jelfa. Collagen and elastic fibres were arranged more uniformly in the dermis and there were numerous fibroblasts, hair follicles, and small vessels. Ultrastructural analysis showed keratinocytes without degenerative changes and the proliferation of lymphatic and dendritic cells in the skin. The results indicate that thymus extracts can have beneficial effects on skin aging, which is often accompanied by hormonal perturbances.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

59

Numer

2

Opis fizyczny

p.311-315,fig.,ref.

Twórcy

  • Department of Pathology, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Centers of Dermatology and Laser Therapy LaserMedic, 20-090 Lublin, Poland
autor
  • Department of Internal Diseases of Farm Animals and Horses, Faculty of Veterinary Medicine, University of Life Sciences, 20-950 Lublin, Poland
autor
  • Department of Pathology, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Pathology, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

  • 1. Ben-Efraim S., Keisari Y., Ophir R., Pecht M., Trainin N., Burstein Y.: Immunopotentiating and immunotherapeutic effects of thymic hormones and factors with special emphasis on thymic humoral factor THF-gamma 2. Crit Rev Immunol 1999, 19, 261-284.
  • 2. Ciechanover A.: The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting, Biochem Soc Trans 2003, 31, 474-481.
  • 3. Comelekoglu U., Yalin S., Ballli E., Mehmet Berkoz M.: Ovariectomy decreases biomechanical quality of skin via oxidative stress in rat. Turk J Med Sci 2012, 42, 201-209.
  • 4. Dasuri K., Zhang L., Ebenezer Ph., Fernandez-Kim S.O., Bruce-Keller A.J., Szweda L.I., Keller J.N.: Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress. Free Radic Biol Med 2011, 51, 1727-1735.
  • 5. Domínguez-Gerpe L, Rey -Méndez M.: Evolution of the thymus size in response to physiological and random events throughout life. Microsc Res Tech 2003, 62, 464-476.
  • 6. Hara T.: Thymosins and muscle regeneration. Vitam Horm 2011, 87, 277-290.
  • 7. Marciniak A., Szpringer E., Lutnicki K., Beltowski J.: Influence of thymus extract (TFX) on lipid peroxidation in the plasma of rats following thermal injury. Bull Vet Inst Pulawy 2003, 47, 231-238.
  • 8. Markiewicz M., Znoyko S., Stawski L., Ghatnekar A., Gilkeson G., Trojanowska M.: A role for estrogen receptor-α and estrogen reeeptor-ß in collagen biosynthesis in mouse skin. J Invest Dermatol 2013, 133, 120-127.
  • 9. Meier N., Langan D., Hilbing H., Bodo E., Farjo N.P., Farjo B., Ambruster F.P., Paus R.: Thymic peptides differentially modulate human hair follicle growth. J Invest Dermatol 2012, 132, 1516-1519.
  • 10. Obminska-Domoradzka B., Szczypka M., Debowy J.: Effects of thymomimetic drugs and zinc supplementation on the cellular immune response in hydrocortisone-suppressed mice. J Vet Med 2002, 49, 469-475.
  • 11. Ozyazgan I., Liman N., Dursun N., Gunes I.: The effects of ovariectomy on the mechanical properties of skin in rats. Maturitas 2002, 43, 65-74.
  • 12. Perisić M., Stoić-Vukanić Z., Pilipowić I., Kosec D., Nacka-Aleksić M., Dikić J., Arsenovié-Ranin N., Leposavic G.: Role of ovarian hormones in T-cell homeostasis: from the thymus to the periphery. Immunobiol 2013, 218, 353-367.
  • 13. Piekarska J., Michalski A., Szczypka M., Obmińska -Mrukowicz B.: Trichinella spiralis: effect of thy mus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009, 123, 128-133.
  • 14. Rossdeutsch A., Smart N., Dube K.N., Turner M., Riley P.R.: Essential role for thymosin ß4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res 2012, 111, 89-102.
  • 15. Shanker A., Singh S.M.: Immunopotentiation in mice bearing a spontaneous transplantable T-cell lymphoma: role of thy mic extract. Neoplasma 2003, 50, 272-279.
  • 16. Smart N., Rossdeutsch A., Riley P.R.: Thymosin beta4 and angiogenesis: modes of action and therapeutic potential. Angiogenes 2007, 10, 229-241.
  • 17. Stanulis-Praeger B.M., Yaar M., Redziniak G., Meybeck A., Gilchrest B.A.: An extract of bovine thy mus stimulates human keratinocyte growth in vitro. J Invest Dermatol 1988, 90, 749-754.
  • 18. Tay S.S., Roediger B., Tong P.L., Tikoo S., Weninger W.: The skin-resident immune network. Curr Dermatol Rep 2013, 28, 13-22
  • 19. Thornton M.J.: The biological actions of estrogens on skin. Exp Dermatol 2002, 11, 487-502.
  • 20. Tsukahara K., Nakagawa H., Moriwaki S., Kakuo S., Ohuchi A., Takema Y., Imokawa G.: Ovariectomy is sufficient to accelerate spontaneous skin ageing and to stimulate ultraviolet irradiation- induced photoaging of murine skin. Br J Dermatol 2004, 151, 984-994.
  • 21. Zimecki M., Artym J., Kocięba M., Kuryszko J., Kaleta-Kuratewicz K., Marycz K.: Calf thy mus extract attenuates severity of experimental encephalomyelitis in Lewis rats. Folia Neuropathol 2010, 48, 246-257.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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