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2014 | 70 | 05 |

Tytuł artykułu

Niektóre nowe dane dotyczące wirusologii i immunologii

Autorzy

Warianty tytułu

EN
Some new data concerning virology and immunology

Języki publikacji

PL

Abstrakty

EN
A newly emerged H7N9 influenza virus isolated from poultry and humans in China. Its nonpathogenic nature in poultry enables avian H7N9 virus replicate silently in avian species, transmit to humans and become more virulent and transmissible in the human population. Eritoran, a potent, well tolerated, synthetic TLR4 antagonist blocks influenza-induced lethality in mice, as well as lung pathology, clinical symptoms and decreases viral titers. It prevents mortality when administrered up to 6 days after infection of mice. Isolation of two giant amoeba viruses without morphological or genomic resemblance to any previously defined virus families. Different roles of type 1 interferons in acute and chronic viral infections. Microbial colonization influences early B-cell development in the gut. BACH2, the key regulator stabilizes Treg-mediated immune homeostasis. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.

Wydawca

-

Rocznik

Tom

70

Numer

05

Opis fizyczny

s.259-263,bibliogr.

Twórcy

autor
  • ul.Puszkina, 8/10, 10-294 Olsztyn

Bibliografia

  • 1. Fouchier R. A. M., Kawoaka Y.: Gain-of-funcion experiments on H7N9. Nature 2013, 500, 150-151; Science 2013, 341, 601.
  • 2. Hooper L. V., Litman D. R., Macpherson A. J.: Interactions between the microbiota and the immune system. Science 2012, 336, 1268-1273.
  • 3. Jaffe H. W., Patterson A. P., Lurie N.: Extra oversight for H7N9 experiments. Nature 2013, 500, 151; Science 2013, 341, 713.
  • 4. Kleinewietfeld M., Manzel A., Titze J., Kvakan H., Yosef N., Linker R. A., Muller D. N., Hafler D. A.: Sodium Chloride drives autoimmune disease by iduction of pathogenic Tн17 cells. Nature 2013, 496, 518-522.
  • 5. Malakoff D.: Critics skeptical as flu scientists argue for controversial H7N9 studies. Science 2013, 341, 601.
  • 6. Odorizzi P. M., Wherry E. J.: An interferon paradox. Science 2013, 340, 155-156.
  • 7. O’Shea J. J., Jones R. G.: Rubbing salt in the wound. Nature 2013, 496, 437-439.
  • 8. Pennisi E.: Ever-Bigger viruses shake tree of life. Science 2013, 341, 226-224.
  • 9. Philippe N., Legendre M., Doutre G., Coute Y., Poirot O., Lescot M., Arslan D., Seltzer V., Bertaux L., Brule O., Garin J., Claverie J.-M., Abergel C.: Pandoraviruses: Amoeba viruses with genomes up to 2,5 mb reaching that of parasitic eukaryotes. Science 2013, 341, 281-286.
  • 10. Roychoudhuri R., Hirahara K., Mousavi K., Clever D., Klebanoff C. A., Bonelli M., Sciume G., Zare H., Vahedi G., Dema B., Yu Z., Liu H., Takahashi H., Rao M., Muransky P., Crompton J. G., Punkosdy G., Bedognetti D., Wang E., Hoffann V., Rivera J., Marincola F. M., Nakamura A., Sartorelli V., Kanno Y., Gattinoni L., Muto A., Igrashi K., O’Shea J. J., Restifo N. P.: BACH2 represses efector programs to stabilize Treg-mediated immune homestasis. Nature 2013, 498, 506-510.
  • 11. Schissel M.: B-cell development in the gut. Nature 2013, 501, 42-43.
  • 12. Shirey K. A., Lai W., Scott A. J., Lipsky M., Mistry P., Pletneva L. M., Karp C. L., McAlees J., Gioannini T. L., Weiss J., Chen W. H., Ernst R. K., Rossignol D. P., Gusovsky F., Blanco J. C. G., Vogel S. N.: The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature 2013, 497, 498-502.
  • 13. Teijaro J. R., Ng C., Lee A. M., Sullivan B. M., Sheehan K. C. F., Welch M., Schreiber R. D., de la Torre J. C., Oldstone M. B. A.: Persistent LCMV infection controlled by blockade of type I interfering signaling. Science 2013, 340, 207-211.
  • 14. Wesemann D. R., Portuguese A. J., Meyers R. M., Gallagher M. P., Cluff-Jones K., Magee J. M., Panchkshari R. A., Rodig S. J., Kepler T. B., Alt F. W.: Microbial colonization influnces early B-lineage development in the gut lamina propria. Nature 2013, 501, 112-115.
  • 15. Wilson E. B., Yamada D. H., Elsaesser H., Herskovitz J., Deng J., Cheg G., Aronow B. J., Karp C. L., Brooks D. G.: Blockade of chronic type I interferon signaling to control persistent CMV infection. Science 2013, 340, 202-207.
  • 16. Wu C., Yosef N., Thalhamer T., Zhu C., Xiao Y., Kishi Y., Regev A., Kuchroo V. K.: Induction of pathogenic Tн17 cells by inducible salt-sensing kinaseSGK1. Nature 2013, 496, 513-517.
  • 17. Zhang Q., Shi J., Deng G., Guo J., Zeng X., He X., Kong H., Gu C., Li X., Liu J., Wang G., Chen Y., Liu L., Liang L., Li Y., Fan J., Wang J., Li W., Guan L., Li Q., Yang H., Chen P., Jiang L., Guan Y., Xin X., Jiang Y., Tian G., Wang X., Qiao C., Li C., Bu Z., Cen H.: H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science 2013, 341, 410-414.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-94758240-5b33-4aab-9574-6c392dae7682
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