Reduced level of synapsin I protein in the rat striatum after intraventricular administration of proteasome inhibitors: preliminary studies

• Autorzy: Wojcik S. , Spodnik J.H. , Sidor-Kaczmarek J. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

Background: We have recently described changes present in nigrostriatal terminals after intraperitoneal administration of MG-132 and changes that occur in the walls of the rat lateral ventricle after intraventricular administration of MG-132, lactacystin and epoxomicin — different classes of proteasome inhibitors. Substances that inhibit ubiquitin-proteasome system (UPS) activity, are intensively studied due to their potential role as novel therapeutic strategies in the treatment of cancer and ischaemia-reperfusion injury in the brain. The aim of this study is to determine the influence of intraventricular administration of MG-132, lactacystin and epoxomicin on the level in the rat striatum synapsin I — one of the most prominent neuron-specific phosphoproteins in the brain. Materials and methods and Results: Two weeks after administration of studied proteasome inhibitors, substantial reduction (up to 80%) of synapsin I was observed in the rat striatum. Because neurons, and especially dopaminergic ones, are sensitive to the depletion of proteasome function, we assume that observed synapsin I decrease may reflect changes in population of striatal neurons and/or nigrostriatal terminals. Conclusions: Understanding of cellular mechanisms standing behind our findings needs further studies, and could provide valuable contribution to the discussion on the mechanisms linking UPS inhibition and survival of neurons. (Folia Morphol 2015; 74, 4: 428–433)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2015
• Tom: 74
• Numer: 4
• Opis fizyczny: p.428-433,fig.,ref.

Twórcy

autor

Wojcik S.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Spodnik J.H.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Sidor-Kaczmarek J.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Morys J.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

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Identyfikatory

DOI

10.5603/FM.2015.0103