The effects of moderate running exercise and L‑tyrosine on penicillin‑induced epileptiform activity in rats

• Autorzy: Kayacan Y. , Kisa E.C. , Ghojebeigloo B.E. , Kocacan S.E. , Ayyildiz M. , Agar E.
• Języki publikacji: EN

Abstrakty

EN

Regular exercise and amino acid supplementation, popular approaches toward the reduction of epileptic seizures, have been extensively researched. This study was conducted to evaluate the effects of treadmill exercise and L-tyrosine treatment on the frequency and amplitude of epileptiform activity in rats. A total of 32 male albino Wistar rats were randomly divided into four groups: control, exercise, L-tyrosine, and exercise + L-tyrosine. L-tyrosine was supplemented by oral gavage (500 mg/kg/day, 2.5 mL solution). The treatments were performed 5 days a week for 10 weeks. The rats were anesthetized and then administered 500 IU penicillin into the left cerebral cortex using a microinjector and electrocorticogram (ECoG) activity was recorded for 3 hours using a Power Lab data acquisition system. The frequency and the amplitude of the ECoG recordings were analyzed offline. Compared to the control group, spike frequency decreased significantly in all other groups. There was no statistically significant difference between the groups in terms of spike amplitude and latency. In this study, the effects of regularly administered treadmill exercise and L-tyrosine use on epileptiform activity were examined and evaluated together for the first time. The results of this study showed that regular exercise and L-tyrosine use decreased epileptiform activity. Further research and clinical trials are needed to investigate the extent to which L-tyrosine and physical activity interfere with the epileptic state by investigating different doses of L-tyrosine and different severity/ time/type of exercise protocols.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2019
• Tom: 79
• Numer: 2
• Opis fizyczny: p.148-154,fig.,ref.

Twórcy

autor

Kayacan Y.

• Faculty of Yasar Dogu Sports Sciences, Ondokuz Mayıs University, Samsun, Turkey

autor

Kisa E.C.

• Faculty of Yasar Dogu Sports Sciences, Ondokuz Mayıs University, Samsun, Turkey

autor

Ghojebeigloo B.E.

• Faculty of Yasar Dogu Sports Sciences, Ondokuz Mayıs University, Samsun, Turkey

autor

Kocacan S.E.

• Health Care Vocational High School, Ondokuz Mayıs University, Samsun, Turkey

autor

Ayyildiz M.

• Department of Physiology of Medicine, Ondokuz Mayıs University, Samsun, Turkey

autor

Agar E.

• Department of Physiology of Medicine, Ondokuz Mayıs University, Samsun, Turkey

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Identyfikatory

DOI

10.21307/ane‑2019‑013