The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes

• Autorzy: Kurek A. , Markowska K. , Grudniak A. M. , Janiszowska W. , Wolska K. I.
• Języki publikacji: EN

Abstrakty

EN

Oleanolic acid and ursolic acid are pentacyclic triterpenoids isolated from a variety of medicinal plants, which have antibacterial activity. Listeria monocytogenes is a Gram-positive facultative pathogen, being the causative agent of listeriosis. The present study was carried out to evaluate the in vitro effect of sub-inhibitory concentrations of both triterpene acids on the pathogenicity determinants of L. monocytogenes: their hemolytic activity and biofilm forming ability. Oleanolic and ursolic acids inhibited listeriolysin O activity without influencing toxin secretion. Biofilm formation, and the viability of L. monocytogenes cells in biofilms was diminished by both compounds. Thus, both acids affected L. monocytogenes virulence. It was also demonstrated that oleanolic acid bound to the peptidoglycan of L. monocytogenes and this interaction was influenced by teichoic acids.

Słowa kluczowe

EN

oleanolic acid; ursolic acid; hemolytic property; biofilm formation; Listeria monocytogenes; listeriolysin O

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2014
• Tom: 63
• Numer: 1
• Opis fizyczny: p.21-25,fig.,ref.

Twórcy

autor

Kurek A.

• Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa St.1, 02-096 Warsaw, Poland

autor

Markowska K.

• Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa St.1, 02-096 Warsaw, Poland

autor

Grudniak A. M.

• Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa St.1, 02-096 Warsaw, Poland

autor

Janiszowska W.

• Department of Plant Biochemistry, Institute of Biochemistry, Faculty of Biology, University of Warsaw, Warsaw, Poland

autor

Wolska K. I.

• Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa St.1, 02-096 Warsaw, Poland

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