Tumor necrosis factor - alpha (TNFalpha) gene polymorphism and expression of membrane - bound TNFalpha protein on CD11bplus and IgMplus cells in cows naturally infected with bovine leukemia virus

• Autorzy: Bojarojc-Nosowicz B. , Kaczmarczyk E. , Stachura A. , Kubinska M.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to determine whether SNP at position -824 (promoter region) of the TNFα gene significantly differentiates the size of IgM+, CD5+ and CD11b+ cell subpopulations and affects the expression of membrane-bound TNFα protein (mTNFα) on these cells and their susceptibility to BLV infections. In this study, significant differences were determined for the first time between TNFα genotypes and the percentage of cells with the CD11b+TNFα+p24+ immunophenotype. Furthermore, greater expansion of lymphocytes with the IgM+TNFα+p24+ immunophenotype was reported in cows with the G/G genotype than in A/A homozygotes. Cells with the above immunophenotype were more frequently observed in cows with persistent leukocytosis than in aleukemic cattle. Our results suggest that polymorphism of the TNFα -824 A>G gene and mTNFα protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2015
• Tom: 18
• Numer: 3
• Opis fizyczny: p.533-539,ref.

Twórcy

autor

Bojarojc-Nosowicz B.

• Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland

autor

Kaczmarczyk E.

• Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland

autor

Stachura A.

• Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland

autor

Kubinska M.

• Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland

Bibliografia

• Bajtay Z, Speth C, Erdei A, Dierich MP (2004) Cutting edge: productive HIV-1 infection of dendritic cells via complement receptor type 3 (CR3, CD11b/CD18). J Immunol 173: 4775-4778.
• Bojarojć-Nosowicz B, Kaczmarczyk E, Stachura A, Kotkiewicz M (2011) Polymorphism in the promoter region of the tumor necrosis factor-alpha gene in cattle herds naturally infected and uninfected with the bovine leukemia virus. Pol J Vet Sci 14: 671-673.
• Bouhlal H, Chomont N, Réquena M, Nasreddine N, Saidi H, Legoff J, Kazatchkine MD, Bélec L, Hocini H (2007) Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner. J Immunol 178: 1086-1095.
• Cantor GH, Pritchard SM, Dequiedt F, Willems L, Kettmann R, Davis WC (2001) CD5 is dissociated from the B-cell receptor in B cells from bovine leukemia virus-infected, persistently lymphocytotic cattle: consequences to B-cell receptor-mediated apoptosis. J Virol 75: 1689-1696.
• Chevallier N, Berthelemy M, Le Rhun D, Lainé V, Levy D, Schwartz-Cornil I (1998) Bovine leukemia virus-induced lymphocytosis and increased cell survival mainly involve the CD11b+ B-lymphocyte subset in sheep. J Virol 72: 4413-4420.
• Depelchin A, Letesson JJ, Lostrie-Trussart N, Mammerickx M, Portetelle D, Burny A (1989) Bovine leukemia virus (BLV)-infected B-cells express a marker similar to the CD5 T cell marker. Immunol Lett 20: 69-76.
• Herbein G, O’Brien WA (2000) Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis. Proc Soc Exp Biol Med 223: 241-257.
• Herbein G, Khan KA (2008) Is HIV infection a TNF receptor signalling-driven disease? Trends Immunol 29: 61-67.
• Juliarena MA, Poli M, Sala L, Ceriani C, Gutierrez S, Dolcini G, Rodriguez EM, Marińo B, Rodriguez-Dubra C, Esteban EN (2008) Association of BLV infection profiles with alleles of the BoLA-DRB3.2 gene. Anim Genet 39: 432-438.
• Kaczmarczyk E, Fiedorowicz A, Bojarojć-Nosowicz B, Majewski M (2004) Profile of peripheral blood lymphocytes in the first months of life of heifers originating from a leukaemic herd. Bull Vet Inst Pulawy 48: 361-366.
• Kaczmarczyk E, Bojarojć-Nosowicz B, Cybulska O (2008) Comparative analysis of an ELISA and fluorescent antibody test for the diagnosis of bovine leukaemia virus infection in cattle. Bull Vet Inst Pulawy 52: 19-22.
• Keefe RG, Choi Y, Ferrick DA, Stott JL (1997) Bovine cytokine expression during different phases of bovine leukemia virus infection. Vet Immunol Immunopathol 56: 39-51.
• Klintevall K, Ballagi-Pordány A, Näslund K, Belák S (1994) Bovine leukaemia virus: rapid detection of proviral DNA by nested PCR in blood and organs of experimentally infected calves. Vet Microbiol 42: 191-204.
• Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, Ohashi K, Onuma M (2005) Imbalance of tumor necrosis factor receptors during progression in bovine leukemia virus infection. Virology 339: 239-248.
• Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, Ohashi K, Onuma M (2006) Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection. Microbes Infect 8: 2163-2171.
• Markiewicz L, Rułka J, Kamiński S (2003) Detection of BLV provirus in different cells by nested-PCR. Bull Vet Inst Pulawy 47: 325-331.
• Meirom R, Moss S, Brenner J (1997) Bovine leukemia virus-gp51 antigen expression is associated with CD5 and IgM markers on infected lymphocytes. Vet Immunol Immunopathol 59: 113-119.
• Miyasaka T, Takeshima SN, Jimba M, Matsumoto Y, Kobayashi N, Matsuhashi T, Sentsui H, Aida Y (2013) Identification of bovine leukocyte antigen class II haplotypes associated with variations in bovine leukemia virus proviral load in Japanese Black cattle. Tissue Antigens 81: 72-82.
• Nishimura M, Maeda M, Yasunaga J, Kawakami H, Kaji R, Adachi A, Uchiyama T, Matsuoka M (2003) Influence of cytokine and mannose binding protein gene polymorphisms on human T-cell leukemia virus type I (hTLV-I) provirus load in HTLV-I asymptomatic carriers. Hum Immunol 64: 453-457.
• Rahman MM, McFadden G (2006) Modulation of tumor necrosis factor by microbial pathogens. PLoS Pathog 2: e4.
• Stoiber H, Frank I, Spruth M, Schwendinger M, Mullauer B, Windisch JM, Schneider R, Katinger H, Ando I, Dierich MP (1997) Inhibition of HIV-1 infection in vitro by monoclonal antibodies to the complement receptor type 3 (CR3): an accessory role for CR3 during virus entry? Mol Immunol 34: 855-863.
• Tsukasaki K, Miller CW, Kubota T, Takeuchi S, Fujimoto T, Ikeda S, Tomonaga M, Koeffler HP (2001) Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. Cancer Res 61: 3770-3774.

Identyfikatory

DOI

10.1515/pjvs-2015-0069