IgG avidity: an important serologic marker for the diagnosis of tick-borne encephalitis virus infection

• Autorzy: Vilibic-Cavlek T. , Barbic L. , Stevanovic V. , Petrovic G. , Mlinaric-Galinovic G.
• Języki publikacji: EN

Abstrakty

EN

A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2016
• Tom: 65
• Numer: 1
• Opis fizyczny: p.119-121,fig.,ref.

Twórcy

autor

Vilibic-Cavlek T.

• Department of Virology, Croatian National Institute of Public Health, Zagreb, Croatia
• School of Medicine University of Zagreb, Zagreb, Croatia

autor

Barbic L.

• Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary, Medicine University of Zagreb, Zagreb, Croatia

autor

Stevanovic V.

• Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary, Medicine University of Zagreb, Zagreb, Croatia

autor

Petrovic G.

• Department of Epidemiology, Croatian National Institute of Public Health, Zagreb, Croatia

autor

Mlinaric-Galinovic G.

• Department of Virology, Croatian National Institute of Public Health, Zagreb, Croatia
• School of Medicine University of Zagreb, Zagreb, Croatia

Bibliografia

• Bogovic P., S. Lotric-Furlan and F. Strle. 2010. What tick-borne encephalitis may look like: clinical signs and symptoms. Travel. Med. Infect. Dis. 8(4): 246–250.
• Donoso-Mantke O., L.S. Karan and D. Růžek. 2011. Tick-borne encephalitis virus: a general overview. In: D. Růžek (ed). Flavivirus Encephalitis. Available from: http://www.intechopen.com/books/ flavivirus-encephalitis/tick-borne-encephalitis-virus-a-general-overview, 2015.02.20.
• Fox J.L., S.L. Hazell, L.H. Tobler and M.P. Busch. 2006. Immunoglobulin G avidity in differentiation between early and late antibody responses to West Nile virus. Clin. Vaccine. Immunol. 13(1): 33–36.
• Gassmann C. and G. Bauer. 1997. Avidity determination of IgG directed against tick-borne encephalitis virus improves detection of current infections. J. Med. Virol. 51(3): 242–251.
• Golubić D. and G. Dobler. 2012. Flaviviruses in the north-west Croatia. Croat. J. Infect. 32(4): 153–157.
• Holzmann H. 2003. Diagnosis of tick-borne encephalitis. Vaccine 21(1): 36–40.
• Kleiter I., W. Jilg, U. Bogdahn and A. Steinbrecher. 2007. Delayed humoral immunity in a patient with severe tick-borne encephalitis after complete active vaccination. Infection 35(1): 26–29.
• Levett P.N., K. Sonnenberg, F. Sidaway, S. Shead, M. Niedrig, K. Steinhagen, G.B. Horsman and M.A. Drebot. 2005. Use of immunoglobulin G avidity assays for differentiation of primary from previous infections with West Nile virus. J. Clin. Microbiol. 43(12): 5873–5875.
• Lindenbach B.D., H.J. Thiel and C.M. Rice. 2007. Flaviviridae: The viruses and their replication, pp. 1101–51. In: Knipe D.M. and P.M. Howley (eds). Fields Virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia.
• Mansfield K.L., N. Johnson, L.P. Phipps, J.R. Stephenson, A.R. Fooks and T. Solomon. 2009. Tick-borne encephalitis virus – a review of an emerging zoonosis. J. Gen. Virol. 90(Pt 8): 1781–1794.
• Niedrig M., A. Nitsche and O. Donoso-Mantke. 2010. Arthropod-borne viruses, pp. 450–457. In: Jerome K.R. (ed) Lennette’s laboratory diagnosis of viral infections, 4th ed. Informa Healthcare, New York.
• Prince H.E., C. Yeh and M. Lapé-Nixon. 2011. Utility of IgM/IgG ratio and IgG avidity for distinguishing primary and secondary dengue virus infections using sera collected more than 30 days after disease onset. Clin. Vaccine. Immunol. 18(11): 1951–1956.
• Saksida A., D. Duh, S. Lotrič-Furlan, F. Strle, M. Petrovec and T. Avšič-Županc. 2005. The importance of tick-borne encephalitis virus, RNA detection for early differential diagnosis of tick-borne encephalitis. J. Clin. Virol. 33: 331–335.
• Stiasny K., J.H. Aberle, V. Chmelik, U. Karrer, H. Holzmann and F.X. Heinz. 2012. Quantitative determination of IgM antibodies reduces the pitfalls in the serodiagnosis of tick-borne encephalitis. J. Clin. Virol. 54(2): 115–120.
• Stiasny K., S.W. Aberle and F.X. Heinz. 2013. Retrospective identification of human cases of West Nile virus infection in Austria (2009 to 2010) by serological differentiation from Usutu and other flavivirus infections. Euro. Surveill. 18(43): pii=20614.

Identyfikatory

DOI

10.5604/17331331.1197285