Punkty uchwytu leków przeciwpasożytniczych

• Autorzy: Boczon K.

Warianty tytułu

EN

The main target-points of some antiparasitic drugs

• Języki publikacji: PL

Abstrakty

EN

The main biochemical target points of some antiparasitic drugs were discussed; nucleic acids and carbohydrate metabolism being the targets for chemotherapeutic attack in Protozoa and microtubules and nervous systems - the targets in helminths.

Słowa kluczowe

PL

parazytologia; pasozyty; choroby pasozytnicze; leczenie przeciwpasozytnicze; leki przeciwpasozytnicze; mechanizm dzialania

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 1988
• Tom: 34
• Numer: 4-6
• Opis fizyczny: s.529-543,bibliogr.

Twórcy

autor

Boczon K.

• Katedra i Zakład Biologii i Parazytologii Lekarskiej, Akademia Medyczna w Poznaniu, Poznań

Bibliografia

• 1. Aziz, M. A.: Ivermectiyn vs. Onchocerciasis. - Parasitol. Today 2, 233-234, 1986.
• 2. Boczoń, K.: Bioenergetics of Trichinella spiralis larvae and effect of same anthelmintics on succinate dehydrogenase of Trichinella spiralis mitochondria. Biochemistry of Parasites and Host-Parasite Relationships. H. van den Bossche, Elsevier North-Holland Biomedical Press, Amsterdam, 589-597, 1976.
• 3. Boczoń, K., Olba, W., Olaszek, M.: The influence of same anthelmintics on the bioenergetic metabolism of Trichinella spiralis and Trichinella pseudospiralis. - Biochem. Pharmacol., 33, 15: 2523-2525, 1984.
• 4. Borgers, M., De Nollin, S., Verheyen, A., De Brabander, M., Thienpont, D.: Effects of new anthelmintics on the microtubular system of parasites. Microtubules and Microtubule Inhibitors. Borgers M. & de Brabander M., North Holland Publishing Company, Amsterdam, 497-508, 1975.
• 5. Van den Bossche, H.: How anthelmintics help us to understand helminths. - Parasitology, 90, 675-685, 1985.
• 6. Campbell, W. C., Fisher, M. H., Stapley, E. O., Albers-Schonberg, G., Jacob, T. A.: Ivermectin: A Patent New Antiparasitic Agent. - Science, 221, 823-828, 1983.
• 7. Campbell, W. C.: Ivermectin: An update. - Parasitol. Today, 1, 10-16, 1985.
• 8. Mc Cann, P. P., Bacchi, C. J., Hanson, W. L., Cain, G. D., Nathan , H. C., Hutner, S. H., Sjoerdsma, A.: Effect on Parasitic Protozoa of α-Difluoromethylornithine - An Inhibitor of Ornithine Decarboxylase. Advances in Polyamine Research. C. M. Caldarera et al., Raven Press, New York, 3, 97-110, 1981.
• 9. Carson, D. A., Chang, K. P.: Phosphorylation and the antileishmanial activity of Formycine B. - Biochem. Biophys. Res. Commun., 100, 1377-1383, 1981.
• 10. Clarkson, A. B., Brohn, F. H.: Trypanosomiasis: An approach to chemotherapy by the inhibition of carbohydrate catabolism. - Science, 194, 204-206, 1976.
• 11. Davidse, L. C., Flach, W.: Interaction of thiabendazole with fungal tubulin. - Biochem. Biophys. Acta, 543, 82-90, 1978.
• 12. Dawson, P. J., Gutteridge, W. E., Gull, K.: Purification and characterization of tubulin from the parasitic nematode Ascaridia galli. - Mol. Biochem. Parasitol., 7, 267-277, 1983.
• 13. Fairlamb, A. H., Bowman, I. B. R.: Trypanosoma brucei: Suramin and Other Trypanocidal Compounds Effects on Glycerol-3-Phosphate Oxidase. - Exp. Parasitol., 43, 355-361, 1977.
• 14. Fairlamb, A. H., Bowman, I. B. R.: Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo. - Mol. Biochem. Parasitol., 1, 315-333, 1980.
• 15. Fetterer, R. H., Pax, R. A., Thompson, D., Bricker, C., Bennett, J. L.: Praziquantel: mode of its antischistosomal action. The Host Invader Interplay. H. van den Bossche, Elsevier North-Holland Biomedical Press, Amsterdam, 695-698, 1980.
• 16. Friedman, P. A., Platzer, E. G.: Interaction of anthelmintic benzimidazole with Ascaris suum embryonic tubulin. - Biochim. Biophys. Acta, 630, 271-278, 1980.
• 17. Gurrero, J., Rohovsky, M. W., van der Westhuizen, B., Mellon, D., Doddi, N.: The use of mebendazole and levamisole in sustained release formulations. The Host Invader Interplay. H. van den Bossche, Elsevier North-Holland Biomedical Press, Amsterdam, 717-722, 1980.
• 18. Henderson, G. B., Fairlamb, A. H.: Trypanothione Metabolism: a Chemotherapeutic Target in Trypanosomatids. - Parasitol. Today, 312-315, 1987.
• 19. James, S.: Thiamine uptake in isolated schizonts of Eimeria tenella and the inhibitory effects of amprolium. - Parasitology, 80, 313-322, 1980.
• 20. Köhler, P.: The function of mitochondrial enzymes in parasitic helminths. Trends in Enzymology, FEBS. Vitale L. & Simeon V. Pergamon Press, Oxford, 61, 243-256, 1980.
• 21. Köhler, P., Bachmann, R.: Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic Nematodes. - Mol. Biochem. Parasitol., 4, 325-336, 1981.
• 22. Lacey, E., Prichard, R. K.: Interactions of benzimidazoles (BZ) with tubulin from BZ-sensitive and BZ-resistant isolates of Haemonchus contortus. - Mol. Biochem. Parasitol., 19, 171-181, 1986.
• 23. Levis, J . A., Wu, C. H., Levine, J. H., Berg, H.: Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. - Neuroscience, 5, 967-989, 1980.
• 24. Lindmark, D. G., Müller, M.: Hydrogenosome, a cytoplasmic organelle of the anaerobie flagellate Trichomonas foetus and its role in pyruvate metabolism. - J. Biol. Chem., 248, 7724-7728, 1973.
• 25. Müller, M.: Action of clinically utilized 5-nitroimidazoles on microorganisms. - Scand. J. Infect. Dis. Suppl., 26, 31-41, 1981.
• 26. Nollin, S., van den Bossche, H.: Biochemical effects of mebendazole on Trichinella spiralis larvae. - J. Parasitol., 59, 970-976, 1973.
• 27. Prichard, R. K., Bachmann, R., Hutchinson, G. W., Köhler, P.: The effect of praziquantel on calcium in Hymenolepis diminuta. - Mol. Biochem. Parasitol., 5, 297-308, 1982.
• 28. Prichard, R. K.: The pharmacology of anthelmintics in livestock. Parasitology Quo - Vadit?, ICOPA VI, 473-482, 1986.
• 29. Reeves, R. E., Guthrie, I. D., Lobelle-Rich, P.: Entamoeba histolytica: Isolation of Ferredoxin. - Exp. Parasitol. 49, 83-88, 1980.
• 30. Rodriguez-Caabeiro, F., Criado-Fornelio, A., Jimenez-Gonzales, A.: A comparative study of the succinate dehydrogenase fumarate reductase complex in the genus Trichinella. - Parasitology, 91, 577-583, 1985.
• 31. Sano, M., Hayashi, M., Terada, M.: Studies on Chemotherapy of Parasitic Helminths. (XIX) Further Examination on in Vitro Effects of Avermectin B₁a. - Jap. J. Parasit., 32, 363-366, 1983.
• 32. Terada, M., Ishii, A. I., Kino, H., Sano, M.: Studies on chemotherapy of parasitic helminths. (VI) Effects of various neuropharmacological agents on the motility of Dipylidium caninum. - Japan. J. Pharmacol., 32, 479-488, 1982a.
• 33. Terada, M., Ishii, A. I., Kino, H., Fujiu, Y., Sano, M.: Studies on chemotherapy of parasitic helminths. (IX) Effects of praziquantel on the motility of various parasitic helminths and host tissues. - Experientia, 38, 549-553, 1982b.
• 34. Terada, M., Fujiu, Y., Sano, M.: Studies on chemotherapy of parasitic helminths. (XVII) Effects of pyrantel on the motility of various parasitic helminths and isolated host tissues. - Experientia, Basel, 39, 1020-1022, 1983.
• 35. Terada, M., Ishii, A. L, Kino, H., Sano, M.: Angiostrongylus cantonensis: Paralysis Due to Avermectin B₁a and Ivermectin. - Exp. Parasitol., 57, 149-157, 1984.
• 36. Wang, Ch. Ch.: Studies on the mitochondria from Eimeria tenella and inhibition of the electron transport by quinolone coccidiostats. - Biochim. Biophys. Acta, 396, 210-219, 1975.
• 37. Wang, C. C.: Parasite Enzymes as Potential targets for Antiparasitic Chemotherapy. - J. Med. Chem., 27, 1-9, 1984.
• 38. Watts, S. D. M., Rapson, E. B., Atkins, A. M., Lee, D. L.: Inhibition of acetylcholinesterase secretion from Nippostrongylus brasiliensis by benzimidazole anthelmintics. - Biochem. Pharmacol., 31, 3035-3040, 1982.
• 39. Weinbach, E. C., Claggett, C. E., Keister, D. B., Diamond, L. S., Hideo, K. : Respiratory metabolism of G. lamblia. - J. Parasitol. 66, 347-350, 1980.
• 40. Yarlett, N., Gorrel, T. E., Marczak, R., Müller, M.: Reduction of nitroimidazole derivatives by hydrogenosomal extracts of Trichomonas vaginalis. - Mol. Biochem. Parasitol., 14, 29-40, 1985.