The role of focal adhesion kinase in the emigration of cells from confluent cultures

• Autorzy: Trembacz H. , Miloszewska J. , Szaniawska B. , Malecki M. , Przybyszewska M. , Skorski T. , Janik P.
• Języki publikacji: EN

Abstrakty

EN

We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin. In conclusion, it can be postulated that FAK plays an important role in the mechanism of contact inhibition.

Słowa kluczowe

EN

focal adhesion kinase; migration; cell; confluent culture; contact inhibition

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 4
• Opis fizyczny: p.1047-1057,fig.,ref.

Twórcy

autor

Trembacz H.

• Department of Cell Biology, Cancer Center, M.Sklodowska-Curie Institute of Oncology, W.K.Roentgen 5, 02-781 Warsaw, Poland

autor

Miloszewska J.

• Department of Cell Biology, Cancer Center, M.Sklodowska-Curie Institute of Oncology, W.K.Roentgen 5, 02-781 Warsaw, Poland

autor

Szaniawska B.

• Department of Cell Biology, Cancer Center, M.Sklodowska-Curie Institute of Oncology, W.K.Roentgen 5, 02-781 Warsaw, Poland

autor

Malecki M.

• Department of Cell Biology, Cancer Center, M.Sklodowska-Curie Institute of Oncology, W.K.Roentgen 5, 02-781 Warsaw, Poland

autor

Przybyszewska M.

• Department of Cell Biology, Cancer Center, M.Sklodowska-Curie Institute of Oncology, W.K.Roentgen 5, 02-781 Warsaw, Poland

autor

Skorski T.

• Center for Biotechnology, Temple University, 1900N 12th Street, Philadelphia, USA

autor

Janik P.

• Department of Cell Biology, Cancer Center, M.Sklodowska-Curie Institute of Oncology, W.K.Roentgen 5, 02-781 Warsaw, Poland

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