Biophysical parameters of rats’ skin after the administration of methimazole

• Autorzy: Golynski M. , Szczepanik M. , Lutnicki K. , Adamek L. , Golynska M. , Wilkolek P. , Sitkowski W. , Kurek L. , Debiak P.
• Języki publikacji: EN

Abstrakty

EN

The paper describes the influence of oral administration of methimazole on biophysical skin parameters. Wistar rats of different sex (220-260 g) were used in the experiment. Biophysical skin parameters, such as transepidermal water loss (TEWL), corneometry, and pH were examined at seven-day intervals. Significant changes in the parameters were observed on the 7th d of methimazole administration. The changes were observed in both sex but males appeared to be less sensitive in that respect. Changes in the parameters in the females showed rapid mechanisms, which normalised transepidermal water loss and skin hydration, as well as restored skin barrier functions. TEWL, skin hydration, and skin pH measurements allow an early assessment of skin barrier dysfunction after administration of this drug.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2014
• Tom: 58
• Numer: 2
• Opis fizyczny: p.315-319,ref.

Twórcy

autor

Golynski M.

• Sub-Department of Internal Diseases of Farm Animals and Horses, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Szczepanik M.

• Sub-Department of Clinical Diagnostics and Veterinary Dermatology, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Lutnicki K.

• Sub-Department of Internal Diseases of Farm Animals and Horses, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Adamek L.

• Sub-Department of Clinical Diagnostics and Veterinary Dermatology, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Golynska M.

• Department and Clinic of Veterinary Surgery Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Wilkolek P.

• Sub-Department of Clinical Diagnostics and Veterinary Dermatology, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Sitkowski W.

• Sub-Department of Clinical Diagnostics and Veterinary Dermatology, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Kurek L.

• Sub-Department of Internal Diseases of Farm Animals and Horses, Clinic of Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

autor

Debiak P.

• Radiology and Ultrasonography Laboratory, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland

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