Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats

• Autorzy: Folwarczna J. , Nowinska B. , Sliwinski L. , Pytlik M. , Cegiela U. , Betka A.
• Języki publikacji: EN

Abstrakty

EN

 Glucocorticoids and β2-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β2-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.

Słowa kluczowe

EN

fenoterol; prednisolone; bone; histomorphometry; glucocorticoid-induced skeletal change; male; rat; mechanical property; bone mineralization

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2011
• Tom: 58
• Numer: 3
• Opis fizyczny: p.313-319,ref.

Twórcy

autor

Folwarczna J.

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

autor

Nowinska B.

autor

Sliwinski L.

autor

Pytlik M.

autor

Cegiela U.

autor

Betka A.

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