Effects of acute administration of L-DOPA on cognitive judgment bias of rats in the ambiguous-cue interpretation paradigm

• Autorzy: Kregiel J. , Golebiowska J. , Rygula R.
• Języki publikacji: EN

Abstrakty

EN

The monoamine serotonin (5-HT) has long been implicated in the modulation of affective and cognitive processing and has been consistently linked to depression, anxiety and negative mood. In the present study, we investigated the effects of acute administration of selective serotonin reuptake inhibitor – escitalopram (S- enantiomer of citalopram) on the valence of cognitive judgment bias of rats in the ambiguous-cue interpretation (ACI) paradigm. In this paradigm the rats are trained to press one lever in response to one tone to receive a reward and to press another lever in answer to a different tone to avoid punishment. Cognitive judgment bias is than tested by measuring the pattern of animals‘ responses to a tone of intermediate frequency (ambiguous-cue). After initial behavioural training, the animals received single injections of 3 different doses of escitalopram and were subsequently tested with the ACI paradigm. The drug was administered using fully randomised Latin square design. Escitalopram (0.5, 1 and 2 mg/kg) had no significant effects on the interpretation of the ambiguous cue by rats. The results are discussed in terms of pharmacological action of escitalopram. Supported by the National Science Centre (Research grant: Sonata bis dec-2012/07/E/NZ4/00196) and the statutory funds of the Institute of Pharmacology PAS.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.358-359

Twórcy

autor

Kregiel J.

• Affective Cognitive Neuroscience Laboratory Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland

autor

Golebiowska J.

• Affective Cognitive Neuroscience Laboratory Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland

autor

Rygula R.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland