A multicarotenoid beadlet for human nutrition - proof of concept of in vitro timed release

• Autorzy: Gellenbeck K. , Salter-Venzon D. , Lala R. , Chavan J.
• Języki publikacji: EN

Abstrakty

EN

Since the 1980's when the predominate focus of study and use of carotenoids in human nutritional formulations was solely on beta-carotene, there has been a steady increase in research aimed to understand the role of a wide variety of carotenoids in human health. This work has increasingly demonstrated the benefits of a number of carotenoids, and there has been a corresponding increase in the number of carotenoids provided in nutritional supplements (multicarotenoids). Numerous published observations in both human and animal studies suggest significant interaction and competition between various carotenoids during absorption and metabolism, resulting in the inhibition of uptake of one over the other. This competition has the end result of reducing the beneficial effects of the inhibited carotenoid. To limit such competition and maximize carotenoid uptakes, a layered beadlet was designed to release a defined ratio of carotenoids sequentially. Preliminary dissolution testing is presented showing the release profile in simulated digestive conditions of a combination of beta-carotene, alpha carotene, lutein, zeaxanthin, lycopene and astaxanthin derived from natural sources. Comparison is made to an immediate release beadlet formulation using the same combination of carotenoids. These results will be used to guide proof of concept clinical testing for effectiveness in humans.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 1
• Opis fizyczny: p.35-38,fig.,ref.

Twórcy

autor

Gellenbeck K.

• Nutrilite Health Institute, Lakeview, California, USA

autor

Salter-Venzon D.

autor

Lala R.

autor

Chavan J.

Bibliografia

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• Applicable Patents and Applications:
• Omniactive Health Technologies (2002) European Patent EP 1 513 804 B1, Australian Patent AU 2002348718 B2, Novel Trans-Lutein Enriched Xanthophyll Ester Concentrate and a Process for its Preparation.
• Omniactive Health Technologies (2005) US Patent Pending US 2005/0095301 A1 - Novel Stable Beadlets of Lipophilic Nutrients.
• Omniactive Health Technologies (2010) Japan Patent Pending 2010-159276 - Novel Trans-Lutein Enriched Xanthophyll Ester Concentrate and a Process for its Preparation.
• Omniactive Health Technologies (2007) India Patent Pending - Novel Time Release Multi Carotenoid Composition and a Process for its Preparation. Application No: 2181/MUM/2007.
• Amway Corporation (2011) US Provisional Patent Application - Multicarotenoid Beadlets, AM1199.

Uwagi

PL

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