Effect of kebar grass extract ( Biophytum petersianum Klotzsch) on histopathological changes in liver of mice offspring from the parent exposed to carbofuran during lactation period

• Autorzy: Yulitasari N.A. , Hidanah S. , Widjiati , Hendrawan V.F. , Luqman E.M.
• Języki publikacji: EN

Abstrakty

EN

This study aims to determine the potential of Kebar grass extract in reducing the impact of liver damage in mice offspring (Mus musculus) from parent exposed to carbofuran during lactation period. 42 lactation mice (Mus musculus) used in the study were divided into seven groups, each group consisting of six mice. Carbofuran, Kebar grass extract, and vitamin C are administered orally on days 1 to 14 after birth. This group consisted of K (aquadest), P1 (carbofuran 1/4 LD50 0.0125 mg/day), P2 (carbofuran 1/8 LD50 0.00625 mg/day), P3 (Kebar grass extract 3.375 mg (0.2 ml) + carbofuran 1/4 LD50), P4 (Kebar grass extract 3.375 mg (0.2 ml) + carbofuran 1/8 LD50), P5 (vitamin C 5 mg (0.2 ml) + carbofuran 1/4 LD50), and P6 (vitamin C 5 mg (0.2 ml) + carbofuran 1/8 LD50). On the 15th day after birth, mice were sacrified and their liver taken for microscopic examination with hematoxilin and eosin staining. The scoring data were analyzed using Kruskal-Wallis and Mann-Whitney test. The result showed significant different (p<0.05) among the treatment groups. Mean of P4 in degeration is (1.13), necrosis (1.13) and inflamation (0.73), while the mean of P6 in degeneration is (2.20), necrosis (2.73) and inflamation (1.93). The conclusion of this research is giving Kebar grass extract is more effective in reducing degeneration, necrosis and inflammatory cell’s infiltration than vitamin C in in mice offspring (Mus musculus) from parent exposed to carbofuran during lactation period.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2021
• Tom: 24
• Numer: 4
• Opis fizyczny: p.573-578,fig.,ref.

Twórcy

autor

Yulitasari N.A.

• Department of Veterinary Science Faculty of Veterinary Medicine Universitas Airlangga Kampus C Unair, Jalan Mulyorejo Surabaya 60115 Indonesia

autor

Hidanah S.

• Department of Veterinary Science Faculty of Veterinary Medicine Universitas Airlangga Kampus C Unair, Jalan Mulyorejo Surabaya 60115 Indonesia

autor

Widjiati

• Department of Veterinary Science Faculty of Veterinary Medicine Universitas Airlangga Kampus C Unair, Jalan Mulyorejo Surabaya 60115 Indonesia

autor

Hendrawan V.F.

• Department of Animal Reproduction Faculty of Veterinary Medicine, Universitas Brawijaya, Jl. MT. Haryono No.169, Ketawanggede, Lowokwaru, Kota Malang, 65144 Indonesia

autor

Luqman E.M.

• Department of Veterinary Science Faculty of Veterinary Medicine Universitas Airlangga Kampus C Unair, Jalan Mulyorejo Surabaya 60115 Indonesia

Identyfikatory

DOI

10.24425/pjvs.2021.139982