Measurements of chemical elements in occupationally exposed hair and their correlation with nephrotoxicity markers in urine

• Autorzy: Marchewka Z. , Dlugosz A. , Gorecka H.
• Języki publikacji: EN

Abstrakty

EN

The possibility of early detection of subclinical changes in the organism of individuals occupationally exposed to chronic action of chemical toxins is a continual subject of study. The analysis of metals in hair is a permanent record of length of exposure and metal circulation. However, such analysis alone cannot be used for the diagnosis of disease. In the presented work we determined the concentrations of Pb, As, Ni, and V in the hair and neutrophil lipocalin (NGAL) in urine, and conducted the correlation between these chemical elements and specific nephrotoxicity indicators in urine: NGAL, N-acetyl- β-D-glucosaminidase (NAG, its isoform NAG-B), β-galactosidase (β-GAL), β-glucuronidase (β-Gr), alanylaminopeptidase (AAP), glutathione transferases (α and π GST), β2-microglobulin (β2M), retinol binding protein (RBP), sialic acids (SIA), albumins and total protein. The studies were conducted on 29 employees of the Polish Fuel Company and on 19 healthy individuals without occupational exposure to chemicals.

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2009
• Tom: 18
• Numer: 6
• Opis fizyczny: p.1059-1064,fig.,ref.

Twórcy

autor

Marchewka Z.

• Laboratory of Environmental Nephrotoxicity Markers, Department of Toxicology, Wroclaw Medical University, Traugutta 57/59, 50-417 Wroclaw, Poland

autor

Dlugosz A.

• Laboratory of Environmental Nephrotoxicity Markers, Department of Toxicology, Wroclaw Medical University, Traugutta 57/59, 50-417 Wroclaw, Poland

autor

Gorecka H.

• Chemistry Department, Institute of Inorganic Technology and Mineral Fertilizers, Wroclaw University of Technology, Wroclaw, Poland

Bibliografia

• 1. STRZELCZYK M., GOCH J., PUCZKOWSKI S., KOPFF M. Elemental analysis of hair In employees of Płock Petrochemistry In the aspect of exposure to neoplastic processes . Prz. Wojs.- Med., 43, (2), 132, 2001 [In Polish].
• 2. KAKKAR P., JAFFERY N.F. Biological markers for metal toxicity. Environ. Toxicol. Pharmacol., 19, 335, 2005.
• 3. ANTONOWICZ-JUCHNIEWICZ J., JODKOWSKA A., KWIECIŃSKA D. Secondary nephropathies In occupational Heath practice. Secondary nephropaties due to occupational exposure. Med. Pr., 57, (4), 389, 2006.
• 4. MORTADA W.I., SOBH M.A., EL-DEFRAWY M.M., FARAHAT S.E. Study of lead exposure from automobile exhaust as a risk for nephrotoxicity among traffic policeman. Am. J. Nephrol., 21, 274, 2001.
• 5. DENNISON J.E., MELVUN E., ANDERSEN B., DOBREV I., MUMTAZ M., YANG R. PBPK modeling of hydrocarbon mixtures: gasoline. Environ. Toxicol. Pharmacol., 16, 107, 2004.
• 6. MARQUARDT H., SCHÄFER S.G., MC CELLAN R., WELSCH F. Toxicology. Academic Press, Melbourne, USA, pp. 760-791, 1999.
• 7. MARCHEWKA Z., STOKŁOSA A., DŁUGOSZ A. Lysosomal enzymes in urine for the assessment of renal function in workers exposed to gasoline. Acta Toxicologica, 13, (2), 77, 2005.
• 8. MARCHEWKA Z., DŁUGOSZ A. Selected biochemical markers to evaluate kidney function in workers expose to petrol. Bromat. Chem. Toksycol, 2, 155, 2003.
• 9. NOWAK B. Contents and relationship of elements in human hair for a non-industrialized population in Poland”, Sci. Total Environ., 59, 209, 1998.
• 10. CHOJNACKA K., GÓRECKA H, CHOJNACKI A., GÓRECKI H. Interelement interactions in human hair. Environmental Toxicology and Pharmacology, 20, 368, 2005.
• 11. VISHWANATHAN H., HEMA A., EDWIN D., RANI M.V. Trace metal concentration in scalp hair of occupationally exposed autodrivers. Environ. Monit. Assessm., 77, 149, 2002.
• 12. OLEJNIK D., KREJPCIO Z., STRUGAŁA-STAWIK H., WÓJCIAK R., GAWĘCKI J. The blond and hair lead contess in children as indices of environmental exposure. Pediatr. Pol., 72, (6), 529, 1997 [In Polish].
• 13. TORRENTEM., COLOMINA M.,T., DOMINGO J.L. Metal concentrations in hair and cognitive assessment in an adolescent population.Biol. Trace Element Research, 104, 215, 2005.
• 14. URBAN J., ANTONOWICZ-JUCHNIEWICZ J., ANDRZEJAK R. Vanadium - threat and hope. Med. Pr., 52, (2), 125, 2001 [In Polish].
• 15. STEFAŃSKA E., KARCZEWSKI J., OSTROWSKA L., CZAPSKA D., HUKAŁOWICZ K., BORAWSKA M., MARKIEWICZ R. Vanadium and chromium kontent In the hair of women with excessive body mass. Bromat. Chem. Toksykol., 36, (2), 151, 2003 [In Polish].
• 16. MANDAL B.K., OGRA Y., ANZAI K., SUZUKI K.T. Speciation of arsenic in biological samples. Toxicol. Appl. Pharmacol., 198, 307, 2004.
• 17. HINWOOD A.L., SIM M.R., JOLLEY D., KLERK N., BASTONE E.B., GEROSTAMOULOS J., DRUMMER O.H. Hair and toenail arsenic concentrations of residents living in areas with high environmental arsenic concentrations. Environ. Health Perspect., 111, (2), 187, 2003.
• 18. NORDBERG G.F., JIN T.I., HONG F., ZHANG A., BUCHET J.P., BERNARD A. Biomarkers of cadmium and arsenic interactions. Toxicol. Appl. Pharmacol., 206, 191, 2005.
• 19. MORROW L.,. NEEDLEMAN HL., MCFARLAND C., METHENY K., TOBIN M. Past occupational to lead: association between current blood lead and bone lead. Arch.Environ.Occup.Health., 62, 183, 2007.
• 20. AFRIDI H.I., KAZI T.G., JAMALI M.K., KAZI G.H., ARAIN M.B., JALBANI N. Evaluation of toxic metals in biological samples (scalp hair, blood and urine) of steel mill workers by electrothermal atomic absorption spectrometry. Toxicol. Ind. Health, 22, 381, 2006.
• 21. KUŹNIAR J., MARCHEWKA Z., LEMBAS-BOGACZYK J., KUŻNIAR J.T., KLINGER M. Etiology of increased enzymuria in different morphological forms of glomerulonephritis. Nephron Physiol. 98, 8, 2004.
• 22. MARCHEWKA Z. Low molecular weight biomarkers in the nephrotoxicity. Adv. Clin. Exp. Med., 15, (6), 1129, 2006.
• 23. GARCON G., LELEU B., MAREZ T., ZERIMECH F., HAGUENOER J., FURON D., SHIRALI P. Biomonitoring of the adverse effects induced by the chronic exposure to lead and cadmium on kidney function: Usefulness of alphaglutathione S-transferase. Sci. Total. Environ., 377, 165, 2007.