EN
Sypniewska, G.: Regulation of new fat cell formation. Acta physiol. pal., 1989, 40 (2): 156-163. The formation of new adipocytes occurs either at the stage of multiplication or differentiation or both. It seems possible that the formation of new fat cells is dependent ion the average cell weight in a given adipose tissue depot, hut there may also be other regional, local regulatory factors. Multiplication iof fat cells has beenx suggested to be stimulated by 17-ß-oestraidiol while the differentiation of adipocytes is stimulated by growth hormone, glucocorticoids, insulin, insulin-like growth factor and female sex hormones. There are, probably, other factions acting in circulation or locally. The factors promoting growth of new fat cells with overfeeding are at present unknown. Some hypothetical possibilities are discussed.