Effect of substrate stiffness on differentiation of umbilical cord stem cells

• Autorzy: Witkowska-Zimny M. , Walenko K. , Walkiewicz A. E. , Pojda Z. , Przybylski J. , Lewandowska-Szumiel M.
• Języki publikacji: EN

Abstrakty

EN

Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 2
• Opis fizyczny: p.261-264,fig.,ref.

Twórcy

autor

Witkowska-Zimny M.

• Department of Biophysics and Human Physiology, Centre of Biostructure Research, Medical University of Warsaw, Warszawa, Poland

autor

Walenko K.

autor

Walkiewicz A. E.

autor

Pojda Z.

autor

Przybylski J.

autor

Lewandowska-Szumiel M.

Bibliografia

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Uwagi

PL

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