Experimental cerebral hemispherectomy in rodent models. A systematic review of current literature

• Autorzy: Morosanu C.O. , Jurca R.L. , Simonca L. , Ilies R.F. , Moldovan R. , Florian S. , Flip G.A.
• Języki publikacji: EN

Abstrakty

EN

Cerebral hemispherectomy is a neurosurgical procedure that involves surgically removing one hemisphere of the brain, used as a therapeutic option in severe cases of intractable epilepsy. Several animal models have contributed to our understanding of the underlying neuromechanisms. The review was based on a PubMed search using the terms “hemispherectomy” and “mouse” or “rat” or “rodent”, with no limitation of year of study or language. We identified a series of elements that were collected and analyzed that add up to our contemporary knowledge of this procedure. Our search returned 29 articles out of which only 15 are relevant to our purposes. Most of the current literature is concerned with the different molecular and electrophysiological issues of neuroplasticity, exhibiting the neurochemical background on which brain plasticity is founded. Experimental neurosurgery is quintessential in understanding the process in which various pathologies respond to in vivo animal models and recreating conditions otherwise difficult or impossible to obtain in humans. The aim of our study was to evaluate the current literature on the modern comprehension that animal models offer for histopathological, neurochemical and microsurgical research. In addition, the review is focused on the neuroplastic/compensatory mechanisms developed after hemispherectomy. Further research is of vital importance in exploring neurotherapeutical aspects of neuroplasticity in central nervous system (CNS) diseases.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2018
• Tom: 78
• Numer: 1
• Opis fizyczny: p.14-20,ref.

Twórcy

autor

Morosanu C.O.

• Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

autor

Jurca R.L.

• Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

autor

Simonca L.

• Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

autor

Ilies R.F.

• Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

autor

Moldovan R.

• Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

autor

Florian S.

• Department of Neurosurgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

autor

Flip G.A.

• Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania

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Identyfikatory

DOI

10.21307/ane‑2018‑003