The influence of heterocyclic compound - PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

• Autorzy: Potkin V.I. , Shcharbin D. , Denisov A. A. , Paschkevich S. G. , Bryszewska M. , Petkevich S. K. , Kletskov A. V. , Lapotko D. O. , Kazbanov V. V. , Gurinovich T. A. , Kulchitsky V. A.
• Języki publikacji: EN

Abstrakty

EN

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

Słowa kluczowe

EN

heterocyclic compound; polyamidoamine dendrimer; 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea; 5-phenyl-isoxazole-3-carboxylic acid; electrical response; hypoxia; brain tissue; brain slice; antitumour effect; isoxazole derivative

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2014
• Tom: 19
• Numer: 2
• Opis fizyczny: p.243-248,fig.,ref.

Twórcy

autor

Potkin V.I.

• Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Shcharbin D.

• Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, Akademicheskaja str.27, Minsk, 220072, Belarus

autor

Denisov A. A.

• Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Paschkevich S. G.

• Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Bryszewska M.

• Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland

autor

Petkevich S. K.

• Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Kletskov A. V.

• Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Lapotko D. O.

• Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA

autor

Kazbanov V. V.

• Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Gurinovich T. A.

• Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

autor

Kulchitsky V. A.

• Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

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