Does central IL-1beta affect GnRH secretion in the hypothalamus of anoestrous ewes via different regulatory pathways?

• Autorzy: Tomaszewska-Zaremba D. , Herman A. P. , Misztal T.
• Języki publikacji: EN

Abstrakty

EN

The study was designed to identify the central pathways through which central interleukin-1β (IL-1β) affects gonadotropin-releasing hormone (GnRH) release in anoestrous ewes. Our results show that intracerebroventricular (icv.) injection of IL-1β (50 µg) decreases the GnRH concentration in the perfusates collected from the medial basal hypothalamus/median eminence (MBH/ME), increases its type I receptor gene expression in the preoptic area, anterior hypothalamus (AHA) and medial basal hypothalamus, and significantly decreases the neuropeptide Y (NPY) mRNA level in the AHA and MBH. No effect of IL-1β treatment was found on plasma cortisol concentration, catecholamine (norepinephrine and dopamine) levels in perfusates, as well as cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) gene expression in the hypothalamus. Our data demonstrate that central IL-1β suppresses GnRH release mainly by acting directly through its own hypothalamic receptors, and its effect could be, at least partially, caused by changes in the NPY level, which is known as an important modulator of GnRH biosynthesis and release.

• Wydawca: -
• Czasopismo: Journal of Animal and Feed Sciences
• Rocznik: 2013
• Tom: 22
• Numer: 1
• Opis fizyczny: p.5-12,fig.,ref.

Twórcy

autor

Tomaszewska-Zaremba D.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Herman A. P.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Misztal T.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

Bibliografia

• Banks W.A., Kastin A.J., Broadwell R.D., 1995. Passage of cytokines across the blood-brain barier. Neuroimmunomodulation 2, 241–248
• Breen K.M., Billings H.J., Debus N., Karsch F.J., 2004. Endotoxin inhibits the surge secretion of gonadotropin-releasing hormone via a prostaglandin-independent pathway. Endocrinology 145, 221–227
• Caldani M., Batailler M., Thiéry J.C., Dubois M.P., 1988. LHRH-immunoreactive structures in the sheep brain. Histochem.Cell Biol. 89, 129–139
• Clarke I.J., Scott C.J., Pereira A., Rawson J., 1999. Levels of dopamine beta hydroxylase immunoreactivity in the preoptic hypothalamus of the ovariectomized ewe following injection of oestrogen: evidence for increased noradrenaline release around the time of estrogen-induced surge in luteinizing hormone. J. Neuroendocrinol. 11, 503–512
• French R.A., VanHoy R.W., Chizzonite R., Zachary J.F., Dantzer R., Parnet P., Bluthé R.M., Kelley K.W., 1999. Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice. J. Neuroimmunol. 93, 194–202
• Givalois L., Dornand J., Mekaouche M., Solier M.D., Bristow A.F., Ixart G., Siaud I., Assenmacher I., Barbanel G., 1994. Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats. Amer. J. Physiol. 267, R164–R170
• Harris T.G., Battaglia D.F., Brown M.E., Brown M.B., Carlson N.E., Vigue C., Williams C.Y., Karsch F.J., 2000. Prostaglandins mediate the endotoxin-induced suppression of pulsatile gonadotropin-releasing hormone and luteinizin hormone secretion in the ewe. Endocrinology 141, 1050–1058
• Herman A,P., Misztal T., Herman A., Tomaszewska–Zaremba D., 2010. Expression of interleukin (IL)-1β and IL-1 receptors genes in the hypothalamus of anoestrous ewes after lipopolysaccharide treatment. Reprod. Domest. Anim. 45, e426–433
• Herman A.P., Misztal T., Romanowicz K., Tomaszewska-Zaremba D., 2012. Central injection of exogenous IL-1b in the control activities of hypothalamic-pituitary-ganadal axis in anestrous ewes. Reprod. Domest Anim. 47, 44–52
• Herman A.P., Tomaszewska-Zaremba D., 2010: Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes. Anim. Reprod. Sci. 120, 105–111
• Hla T., Farrell M., Kumar A., Bailey J.M., 1986. Isolation of the cDNA for human prostaglandin H synthase. Prostaglandins 32, 829–845
• Hla T., Neilson K., 1992. Human cyclooxygenase-2 cDNA. Proc. Natl Acad. Sci. USA. 89,7384–7388
• Huang J.C., Liu D.Y., Yadollahi S., Wu K.K., Dawood M.Y.,1998. Interleukin-1 beta induces cyclooxygenase-2 gene expression in cultured endometrial stromal cells. J. Clin. Endocrinol. Metab. 83, 538–541
• Igaz P., Salvi R., Rey J.P., Glauser M., Pralong F.P., Gaillard R.C., 2006. Effects of cytokines on gonadotropin-releasing hormone (GnRH) gene expression in primary hypothalamic neurons and in GnRH neurons immortalized conditionally. Endocrinology 147, 1037–1043
• Kalra S.P., Crowley W.R., 1984. Norepinephrine-like effects of neuropeptide Y on the LH release in the rat. Life Sci. 35, 1173–1176
• Kalra P.S., Sahu A., Kalra S.P., 1990. Interleukin-1 inhibits the ovarian steroid-induced hormone surge of hypothalamic luteinizing hormone-releasing hormone in rats. Endocrinology 126, 2145–2152
• Kang S.S., Kim S.R., Leonhardt S., Jarry H., Wuttke W., Kim K., 2000. Effect of interleukin-1β on gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in castrated male rats. J. Neuroendocrinol. 12, 421–429
• Kang S.S., Son G.H., Seong J.Y., Choi D., Kwon H.B., Lee C.C., Kim K., 1998. Noradrenergic Neurotoxin suppresses gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in ovariectomized and steroid-treated rats. J. Neuroendocrinol. 10, 911–918
• Kaynard A.H., Pau K.Y.F., Hess D.L., Spies H.G., 1990. Third ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion In ovariectomized rhesus macaques. Endocrinology 127, 2437–2444
• Łapot M., Ciechanowska., Malewski T., Misztal T., Mateusiak K., Przekop F., 2007. The effect of stress on the expression of GnRH
• and GnRH receptor genes in discrete regions of hypothalamus and pituitary of anestrous ewes. Reprod. Biol 7, 55–71
• McDonald J.K., Lumpkin M.D., DePaolo L.V., 1989. Neuropeptide Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: Possible site action. Endocrinology 125, 186–191
• McMahan C.J., Slack J.L., Mosley B., Cosman D., Lupton S.D., Brunton L.L., Grubin C.E., Wignall J.M., Jenkins N.A., Brannan C.I., 1991. A novel Il-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10, 2821–2832
• McShane T.M., May T., Miner J.L., Keisler D.H., 1992. Central actions of neuropeptide Y may provide a neuromodulatory link between nutrition and reproduction. Biol Reprod. 46, 1151–1157
• Misztal T., Górski K., Tomaszewska-Zaremba D., Fülöp F., Romanowicz K., 2010. Effects of a structural analogue of salsolinol, 1-MeDIQ, on pituitary prolactin release and dopaminergic activity in the mediobasal hypothalamus in nursing sheep. Brain Res. 1307, 72–77
• Pfaffl M.W., 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucl. Acids Res. 29, E45
• Pfaffl M.W., Horgan G.W., Dempfle L., 2002. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucl. Acids Res. 30, E36
• Pfaffl M.W., Tichopad A., Prgomet C., Neuvians T.P., 2004. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper – Excel-based tool using pair-wise correlations. Biotechnol. Lett. 26, 509–515
• Porter D.W.F., Naylor A.M., McNeilly A.S., Lincoln D.W., 1993. Endocrine actions of central neuropeptide Y in the ewe: activation of the hypothalamo-pituitary- adrenal axis by exogenous neuropeptide Y and role of endogenous neuropeptide Y in the secretion of luteinizing hormone during the oestrous cycle. J. Neuroendocrinol. 5, 163–174
• Rettori V., Gimeno M.F., Karara A., Gonzalez M.C., McCann S.M., 1991. Interleukin-1 alpha inhibits prostaglandin E2 release to suppress pulsatile release of luteinizing hormone but not follicle-stimulating hormone. Proc. Nat. Aca. Sci. USA 88, 2763–2767
• Rivest S., Lee S., Attardi B., Rivier C., 1993. The chronic intracerebroventricular infusion of interleukin-1β alters the activity of the hypothalamic–pituitary–gonadal axis of cycling rats. I. Effect on LHRH and gonadotropin biosynthesis and secretion. Endocrinology 133, 2424–2430
• Roa J., Herbison A.E., 2012. Direct regulation of GnRH neuron excitability by arcuate Nucleus POMC and NPY neuron neuropeptides in female mice. Endocrinology 153, 5587–5599
• Silverman A.J., 1994. The gonadotropin releasing-hormone (GnRH) neuronal systems: immunocytochemistry. In: E. Knobil and J.D. Neill (eds). The Physiology of Reproduction. Raven Press, New York
• Sirivelu M.P., Burnett R., Shin A.C., Kim C., Mohan-Kumar P.S., Mohan-Kumar S.M.J., 2009. Interaction between GABA and norepinephrine in interleukin-1β-induced suppression of the luteinizing hormone surge. Brain Res. 1248, 107–114
• Traczyk W., Przekop F., 1963. Methods of investigation of the function of the hypothalamus and hypophysis in chronic experiments in sheep. Acta Physiol. Pol. 14, 217–226
• Tomaszewska-Zaremba D., Mateusiak K., Przekop F., 2002. The involvement of GABAA receptors in the control of GnRH and b-endorphin release, and catecholaminergic activity in the preoptic area in anestrous ewes. Exp. Clin. Endocrinol. Diabetes 110, 336–342
• Tomaszewska-Zaremba D., Przekop F., 2005. Effects of GABAB receptor modulation on gonadotropin-releasing hormone and beta-endorphin release, and catecholaminergic activity in the ventromedial hypothalamus-infundibular nucleus region of anoestrous ewes. J. Neuroendocrinol. 17, 49–56
• Vellucci S.V., Parrott R.F., da Costa A.C., Ohkura S., Kendrick K.M. 1995. Increased body temperature, cortisol secretion, and hypothalamic expression of c-fos, corticotrophin releasing hormone and interleukin-1 beta mRNAs, following central administration of interleukin-1 beta in the sheep. Brain Res. Mol Brain Res. 29, 64–70
• Wang Q., Abreu M.T.H., Siminovitch K., Downey G.P., McCulloch C.A., 2006. Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling. J. Biol. Chem. 281, 31093–31105
• Watanobe H., Hayakawa Y., 2003. Hypothalamic interleukin-1β and tumor necrosis factor-α, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Endocrinology 144, 4868–4875
• Wong P.T., Teo W.L., Lee T. 1993. A microdialysis study on striatal dopamine, 5-HT and metabolites in conscious rats after various treatments: evidence for extravesicular release od dopamine. Neuroreport. 5, 53–56
• Wójcik-Gładysz A., Misztal T., Wańkowska M., Romanowicz K., Polkowska., 2003. Effect of central infusions of neuropeptide Y on GnRH/LH axis in ewes during the early anoestrous period. Reprod. Biol. 3, 29–46
• Yoo M. J., Nishihara M., Takahashi M., 1997. Involvement of prostaglandins In suppression of gonadotropin-releasing hormone pulse generator activity by tumor necrosis factor-a. J. Reprod. Dev. 43, 181–187