Antimicrobial activity and cytotoxicity of picolinic acid and selected picolinates as new potential food preservatives

• Autorzy: Borawska M. H. , Czechowska S. K. , Markiewicz R. , Palka J. , Swislocka R. , Lewandowski W.
• Języki publikacji: EN

Abstrakty

EN

In this study antimicrobial activity of picolinic acid (PA), sodium picolinate (PS), potassium picolinate (PP), benzoic acid (BA), sodium benzoate (BS) and potassium benzoate (BP) against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans were measured using microbroth dilution method. Cytotoxicity assay of PS and BS was estimated in the human skin fibroblasts using Thiazolyl Blue Tetrazolium Bromide (MTT) test and DNA-binding assay. PA and PS showed antimicrobial activity at concentrations 0.02 to 0.78 mg/mL at pH=5.0 and 0.19 to 3.13 mg/mL at pH=7.0. Minimal inhibitory concentration (MIC) of BA on tested microorganisms was found at 0.13-0.50 mg/mL (pH=5.0) and about 1 mg/mL at pH=7.0. PA and PS showed strong antimicrobial activity, without significant influence on DNA synthesis and survival of human fibroblasts. The data suggest that PA and PS may represent new potential food preservatives.

• Wydawca: -
• Czasopismo: Polish Journal of Food and Nutrition Sciences
• Rocznik: 2008
• Tom: 58
• Numer: 4
• Opis fizyczny: p.415-418,fig.,ref.

Twórcy

autor

Borawska M. H.

• Department of Bromatology, Medical University of Bialystok, Kilinskiego Str. 1, 15-089 Bialystok, Poland

autor

Czechowska S. K.

autor

Markiewicz R.

autor

Palka J.

autor

Swislocka R.

autor

Lewandowski W.

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Uwagi

PL

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