Effect of Val66Met polymorphism in BDNF on attentional bias in an extroverted Chinese Han population

• Autorzy: Gong P. , Xi S. , Li S. , Cao G. , Zhang P. , Shen G. , Zhang F. , Shen Y. , Ma H.
• Języki publikacji: EN

Abstrakty

EN

Studies have indicated that a functional polymorphism (Val66Met) in a brain-derived neurotrophic factor (BDNF) gene can influences human cognitive functions and mood disorders. In this study, we examined associations of BDNF Val66Met with attentional bias and personality in an unaffected population. The results showed that BDNF Val66Met was significantly associated with attentional disengagement for positive cueing words in extraverts. Moreover, there was a positive correlation between the dosages of Met allele and attentional disengagement, however, we did not observe any significant influences of BDNF Val66Met on personality traits. These preliminary results indicate that the individual differences in attentional bias for positive words are partially underpinned by BDNF.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: 2
• Opis fizyczny: p.280-288,ref.

Twórcy

autor

Gong P.

• College of Medicine, Henan University of Science and Technology, Luoyang, China
• Institute of Applied Psychology, Northwest University, Xi'an, China

autor

Xi S.

• Laboratory of Pharmacology and Medical Molecular Biology, Henan University of Science and Technology, Luoyang, China

autor

Li S.

• College of Medicine, Henan University of Science and Technology, Luoyang, China

autor

Cao G.

• College of Medicine, Henan University of Science and Technology, Luoyang, China

autor

Zhang P.

• College of Medicine, Henan University of Science and Technology, Luoyang, China

autor

Shen G.

• College of Medicine, Henan University of Science and Technology, Luoyang, China

autor

Zhang F.

• Institute of Applied Psychology, Northwest University, Xi'an, China

autor

Shen Y.

• College of Medicine, Henan University of Science and Technology, Luoyang, China

autor

Ma H.

• College of Medicine, Henan University of Science and Technology, Luoyang, China

Bibliografia

• Amado I, Bourdel MC, Daban C, Poirier MF, Loo H, Bouhours P, Krebs MO (2009) Preattentional processes and disorganization in schizophrenia: Influence of a 6-week risperidone treatment. Prog Neuropsychopharmacol Biol Psychiatry 33: 1107-1112.
• Asmundson GJ, Carleton RN, Ekong J (2005) Dot-probe evaluation of selective attentional processing of pain cues in patients with chronic headaches. Pain 114: 250-256.
• Becker M W, Leinenger M (2011) Attentional selection is biased toward mood-congruent stimuli. Emotion 11: 1248¬1254.
• Brosan L, Hoppitt L, Shelfer L, Sillence A, Mackintosh B (2011) Cognitive bias modification for attention and inter¬pretation reduces trait and state anxiety in anxious patients referred to an out-patient service: results from a pilot study. J Behav Ther Exp Psychiatry 42: 258-264.
• Canli T, Zhao Z, Desmond JE, Kang E, Gross J, Gabrieli JD (2001) An fMRI study of personality influences on brain reactivity to emotional stimuli. Behav Neurosci 115: 33-42.
• Cerasa A, Tongiorgi E, Fera F, Gioia MC, Valentino P, Liguori M, Manna I, Zito G, Passamonti L, Nistico R, Quattrone A (2010) The effects of BDNF Val66Met polymorphism on brain function in controls and patients with multiple scle¬rosis: an imaging genetic study. Behav Brain Res 207: 377-386.
• Chao HF (2010) Inhibition of return to negative emotion: evidence from an emotional expression detection task. Emotion 10: 272-277.
• Cisler JM, Bacon AK, Williams NL (2009) Phenomenological Characteristics of Attentional Biases Towards Threat: A Critical Review. Cognit Ther Res 33: 221-234.
• Cisler JM, Koster EH (2010) Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review. Clin Psychol Rev 30: 203-216.
• Conway CA, Jones BC, DeBruine LM, Little AC (2008) Evidence for adaptive design in human gaze preference. Proc Biol Sci 275: 63-69.
• De Raedt R, Koster EH (2010) Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework. Cogn Affect Behav Neurosci 10: 50-70.
• Demeter E, Hernandez-Garcia L, Sarter M, Lustig C (2011) Challenges to attention: a continuous arterial spin labeling(ASL) study of the effects of distraction on sus¬tained attention. Neuroimage 54: 1518-1529.
• Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R (2012) The acute effects of intranasal oxytocin on auto¬matic and effortful attentional shifting to emotional faces. Psychophysiology 49: 128-137.
• Ellenbogen MA, Schwartzman AE (2009) Selective attention and avoidance on a pictorial cueing task during stress in clinically anxious and depressed participants. Behav Res Ther 47: 128-138.
• Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3 : a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39: 175-191.
• Fisher A, Thiessen E, Godwin K, Kloos H, Dickerson J (2012) Assessing selective sustained attention in 3- to 5-year-old children: Evidence from a new paradigm. J Exp Child Psychol 114: 275-294.
• Frustaci A, Pozzi G, Gianfagna F, Manzoli L, Boccia S (2008) Meta-analysis of the brain-derived neurotrophic factor gene(BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. Neuropsychobiology 58: 163-170.
• Gibson BS, Amelio J (2000) Inhibition of return and atten¬tional control settings. Percept Psychophys 62: 496¬504.
• Gong P, Zheng A, Chen D, Ge W, Lv C, Zhang K, Gao X, Zhang F (2009) Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population. J Mol Neurosci 38: 250-256.
• Gong Y (1986) Manual of the Eysenck Personality Questionnaire (in Chinese). Hunan Medical College, Changsha, China, p. 8.
• Hanson IM, Seawright A, van Heyningen V (1992) The human BDNF gene maps between FSHB and HVBS1 at the boundary of 11p13-p14. Genomics 13: 1331-1333.
• Helzer EG, Connor-Smith JK, Reed MA (2009) Traits, states, and attentional gates: temperament and threat relevance as predictors of attentional bias to social threat. Anxiety Stress Coping 22: 57-76.
• Hunt C, Keogh E, French CC (2006) Anxiety sensitivity: the role of conscious awareness and selective attentional bias to physical threat. Emotion 6: 418-428.
• Hunt C, Keogh E, French CC (2007) Anxiety sensitivity, conscious awareness and selective attentional biases in children. Behav Res Ther 45: 497-509.
• Hwang IK, Yoo KY, Jung BK, Cho JH, Kim DH, Kang TC, Kwon YG, Kim YS, Won MH (2006) Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Exp Neurol 201: 75-83.
• Ishizaki J, Meguro K, Nara N, Kasai M, Yamadori A (2012) Impaired shifting of visuospatial attention in Alzheimer's disease as shown by the covert orienting paradigm: Implications for visual construction disability. Behav Neurol 26: 121-129.
• Jongen EM, Smulders FT (2007) Sequence effects in a spatial cueing task: endogenous orienting is sensitive to orienting in the preceding trial. Psychol Res 71: 516-523.
• Keogh E, Dillon C, Georgiou G, Hunt C (2001) Selective attentional biases for physical threat in physical anxiety sensitivity. J Anxiety Disord 15: 299-315.
• Keselman HJ, Cribbie R, Holland B (2002) Controlling the rate of Type I error over a large set of statistical tests. Br J Math Stat Psychol 55: 27-39.
• Kremeyer B, Herzberg I, Garcia J, Kerr E, Duque C, Parra V, Vega J, Lopez C, Palacio C, Bedoya G, Ospina J, Ruiz- Linares A (2006) Transmission distortion of BDNF vari¬ants to bipolar disorder type I patients from a South American population isolate. Am J Med Genet B Neuropsychiatr Genet 141B: 435-439.
• Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T, Kunz D, Gallinat J (2005) Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology(Berl) 180: 95-99.
• Lau JY, Goldman D, Buzas B, Hodgkinson C, Leibenluft E, Nelson E, Sankin L, Pine DS, Ernst M (2010) BDNF gene polymorphism(Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage 53: 952-961.
• Le HB, Ma SH, Cheng XL, Wang ZX, Hu ZG, Zhang HH, Qiu CL, Li H, Zhang GW, Liao LM (2009) Attentional bias for negative emotional facial expressions in major depressive disorder (in Chinese). Chinese Mental Health Journal 23: 795-799.
• Li B, Arime Y, Hall FS, Uhl GR, Sora I (2010) Impaired spa¬tial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice. Eur J Pharmacol 628: 104-107.
• Minelli A, Zanardini R, Bonvicini C, Sartori R, Pedrini L, Gennarelli M, Bocchio-Chiavetto L (2011) BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects. Eur Arch Psychiatry Clin Neurosci 261: 323-329.
• Miyajima F, Ollier W, Mayes A, Jackson A, Thacker N, Rabbitt P, Pendleton N, Horan M, Payton A (2008) Brain-derived neurotrophic factor polymorphism Val66Met influences cog¬nitive abilities in the elderly. Genes Brain Behav 7: 411-417.
• Mogg K, Holmes A, Garner M, Bradley B P (2008) Effects of threat cues on attentional shifting, disengagement and response slowing in anxious individuals. Behav Res Ther 46: 656-667.
• Nakagawa A, Sukigara M (2012) Difficulty in disengaging from threat and temperamental negative affectivity in early life: a longitudinal study of infants aged 12-36 months. Behav Brain Funct 8: 40.
• Neves-Pereira M, Cheung J K, Pasdar A, Zhang F, Breen G, Yates P, Sinclair M, Crombie C, Walker N, St Clair DM (2005) BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 10: 208-212.
• Perlman SB, Morris JP, Van der Wyk BC, Green SR, Doyle JL, Pelphrey KA (2009) Individual differences in personal¬ity predict how people look at faces. PLoS One 4: e5952.
• Ribeiro L, Busnello J V, Cantor RM, Whelan F, Whittaker P, Deloukas P, Wong M L, Licinio J (2007) The brain-de¬rived neurotrophic factor rs6265(Val66Met) polymor¬phism and depression in Mexican-Americans. Neuroreport 18: 1291-1293.
• Rinck M, Becker ES, Kellermann J, Roth WT (2003) Selective attention in anxiety: distraction and enhancement in visual search. Depress Anxiety 18: 18-28.
• Rusting CL (1998) Personality, mood, and cognitive process¬ing of emotional information: three conceptual frame¬works. Psychol Bull 124: 165-196.
• Rusting CL (1999) Interactive effects of personality and mood on emotion-congruent memory and judgment. J Pers Soc Psychol 77: 1073-1086.
• Sasieni PD (1997) From genotypes to genes: doubling the sample size. Biometrics 53: 1253-1261.
• Spector IP, Pecknold JC, Libman E (2003) Selective atten¬tional bias related to the noticeability aspect of anxiety symptoms in generalized social phobia. J Anxiety Disord 17: 517-531.
• Sreenivasan KK, Jha AP (2007) Selective attention sup¬ports working memory maintenance by modulating perceptual processing of distractors. J Cogn Neurosci 19: 32-41.
• Terracciano A, Tanaka T, Sutin A R, Deiana B, Balaci L, Sanna S, Olla N, Maschio A, Uda M, Ferrucci L, Schlessinger D, Costa PT (2010) BDNF Val66Met is asso¬ciated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 35: 1083-1089.
• Toplak ME, Sorge GB, Benoit A, West RF, Stanovich KE (2010) Decision-making and cognitive abilities: A review of associations between Iowa Gambling Task performance, executive functions, and intelligence. Clin Psychol Rev 30: 562-581.
• Wang L, Ashley-Koch A, Steffens DC, Krishnan KR, Taylor WD (2012) Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sad¬ness and executive function. Genes Brain Behav 11: 352¬359.
• Wieser MJ, McTeague LM, Keil A (2011) Sustained preferen¬tial processing of social threat cues: bias without competi¬tion? J Cogn Neurosci 23: 1973-1986.
• Wang YN, Zhou LM, Luo YJ (2008) The pilot establishment and evaluation of Chinese affective words system (in Chinese). Chinese Mental Health Journal 22: 608-612.
• Zhou J, Bradford HF, Stern GM (1996) Induction of dop- aminergic neurotransmitter phenotype in rat embryonic cerebrocortex by the synergistic action of neurotrophins and dopamine. Eur J Neurosci 8: 2328-2339.

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