Old trangenic rats with overexpression of NMP-9 are more active than controls and remember better in behavioral tests

• Autorzy: Wawrzynaik M. , Kiryk A. , Lioudyno N. , Meyza K. , Owczarek D. , Kaczmarek L.
• Języki publikacji: EN

Abstrakty

EN

Matrix metalloproteinases are a major group of enzymes regulating cell-matrix composition, which are essential for many biological processes. Matrix Metalloproteinase-9 (MMP-9) has recently emerged as an important molecule in control of extracellular proteolysis in the synaptic plasticity. Using conventional transgenesis, we have created rats with overexpression of MMP-9 limited to the neurons of the hippocampus, cerebral cortex and cerebellum (MMP-9-gene is under control of neuronal, synapsin-1 promoter). A battery of behavioral tests, including Open Field and Elevated Plus Maze tests, revealed no signifi cant difference between young transgenic and control rats. However, age-related changes in expression level of MMP-9 in wild type rats led to some dysfunctions in behavior, as we noticed differences in general activity between the transgenic and wild type rats increasing with age. The old transgenic rats demonstrated higher activity and better motor functions and coordination than controls. Moreover, the level of anxiety was decreased in the old transgenic rats in comparison with their wild type siblings. Also, the old transgenic rats showed better taste memory than wild type. These results strongly suggest that MMP-9 may have an important role in control of the behavior of animals.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.371

Twórcy

autor

Wawrzynaik M.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Kiryk A.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Lioudyno N.

• Pavlov Department of Physiology, Institute for Experimental Medicine, North-West Branch of the Russian Academy of Medical Sciences, Saint Petersburg, Russia

autor

Meyza K.

• Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Owczarek D.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Kaczmarek L.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland