The occurrence of resveratrol in foodstuffs and its potential for supporting cancer prevention and treatment. A review

• Autorzy: Dybkowska E. , Sadowska A. , Swiderski F. , Rakowska R. , Wysocka K.
• Języki publikacji: EN

Abstrakty

EN

Over recent years, there has been increasing interest noted in those active substances derived from plants that show potential for preventing cancer development. The most promising candidate is resveratrol which can be found in large amounts in the skin of grapes, tomatoes and in red wine. Its beneficial effects on the human body are seen both in prevention and therapy. The anti-carcinogenic action of resveratrol is linked with its ability to neutralise reactive oxygen species and to modulate cellular processes such as apoptosis, and both cancerous cell proliferation and differentiation. This article presents the characteristics of resveratrol as a bioactive compound derived from natural sources exhibiting anti-cancer properties, which, because of a wide spectrum of biological activities may be used in the prevention of cancer. Many in vitro and animal-based studies have demonstrated such preventative anti-cancer action in the colon, prostate, breast and lungs. The beneficial effects of resveratrol are also presented when adopted as a support to conventional treatments of cancer using chemo- and radio-therapy.

PL

W ciągu ostatnich lat wzrosło zainteresowanie biologicznie czynnymi związkami pochodzenia roślinnego, które mogłyby ograniczyć rozwój chorób nowotworowych. Do najważniejszych z nich zalicza się resweratrol, występujący w większej ilości w skórce winogron, pomidorów i czerwonym winie. Resweratrol wykazuje korzystne oddziaływanie profilaktyczne i terapeutyczne na organizm. Przeciwnowotworowe działanie reswerastrolu związane jest z jego zdolnością do neutralizowania reaktywnych form tlenu oraz modulującym oddziaływaniem na procesy apoptozy, proliferacji i różnicowania komórek nowotworowych. Niniejsza praca przedstawia charakterystykę resweratrolu jako związku bioaktywnego pochodzenia naturalnego o działaniu przeciwnowotworowym, który dzięki szerokiemu spektrum działania biologicznego może mieć zastosowanie w chemoprewencji nowotworów. Przeciwnowotworowa aktywność tego związku została dowiedziona w licznych badaniach in vitro oraz na zwierzętach, w których wykazano działanie zapobiegawcze resweratrolu w stosunku do nowotworów: jelita grubego, gruczołu krokowego, piersi, a także płuc. Przedstawiono również jego korzystne oddziaływanie wspomagające standardowe leczenie nowotworów przy zastosowaniu chemioterapii i radioterapii.

Słowa kluczowe

EN

occurrence; resveratrol; foodstuff; potential; human disease; cancer; prevention; treatment

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2018
• Tom: 69
• Numer: 1
• Opis fizyczny: p.5-14,fig.,ref.

Twórcy

autor

Dybkowska E.

• Department of Functional Food, Ecological Food and Commodities, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland

autor

Sadowska A.

• Department of Functional Food, Ecological Food and Commodities, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland

autor

Swiderski F.

• Department of Functional Food, Ecological Food and Commodities, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland

autor

Rakowska R.

• Department of Functional Food, Ecological Food and Commodities, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland

autor

Wysocka K.

• Department of Functional Food, Ecological Food and Commodities, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland

Bibliografia

• Abril M., Negueruela A.I., Pérez C., Juan T., Estopañán G.: Preliminary study of resveratrol content in Aragón red and rosé wines. Food Chem., 2005;92(2):729-736 doi:10.1016/j.foodchem.2004.08.034.
• Aggarwal B.B., Bhardwaj A., Aggarwal R.S., Seeram N.P., Shishodia S., Takada Y.: Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res., 2004;24(5A):2783- 2840.
• Alarcon de la Lastra C., Villegas I.: Resveratrol as an antioxidant and prooxidant agent: mechanisms and clinical implications. Biochem. Soc. Trans., 2007;35(Pt 5):1156-1160 doi:10.1042/BST0351156.
• Almeida L., Vaz-da-Silva M., Falcão A., Soares E., Costa R., Loureiro A., Fernandes-Lopes C., Rocha J.F., Nunes T., Wright L., Soares-da-Silva P.: Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol. Nutr. Food Res., 2009;53(Suppl 1):S7-15 doi:10.1002/mnfr.200800177.
• Athar M., Back J.H., Tang X., Kim K.H., Kopelovich L., Bickers D.R., Kim A.L.: Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol. Appl. Pharmacol., 2007;224(3):274-283 doi:10.1016/j.taap.2006.12.025.
• Aziz M.H., Afaq F., Ahmad N.: Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in surviving. Photochem. Photobiol., 2005;81(1):25-31 doi:10.1562/2004-08-13- RA-274.
• Baatout S., Derradji H., Jacquet P., Ooms D., Michaux A., Mergeay M.: Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol, International Journal of Molecular Medicine, 2004; 13: 895-902.
• Banerjee S., Bueso-Ramos C., Aggarwal B.B.: Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factorkappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Research., 2002;62(17):4945-4954.
• Berge G., Ovrebo S., Botnen I.V., Hewer A., Phillips D.H., Haugen A., Mollerup S.: Resveratrol inhibits benzo[α]pyrene-DNA adduct formation in human bronchial epithelial cells. Br. J. Cancer., 2004;91(2):333- 338 doi:10.1038/sj.bjc.6601898.
• Bobrowska B., Tokarz A., Grynkiewicz G.: Cancer induction in DMBA-treated rats in relation to diet. Bromat. Chem. Toksykol., 2009; 42(3): 1017-1023 (in Polish).
• Brown V.A., Patel K.R., Viskaduraki M., Crowell J.A., Perloff M., Booth T.D., Vasilinin G., Sen A., Schinas A.M., Piccirilli G., Brown K., Steward W.P., Gescher A.J., Brenner6 D.E.: Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics and Effect on the Insulin-like Growth Factor Axis. Cancer Res., 2010;70(22):9003-9011 doi:10.1158/0008-5472.CAN- 10-2364.
• Bruno R., Ghisolfi L., Priulla M., Nicolin A., Bertelli A.: Wine and tumors: study of resveratrol. Drugs Exp Clin Res, 2003;29(5-6):257-261.
• Cai Y., Zhao L., Qin Y., Zhang M., He Y.: Resveratrol inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through AMPK activation. Pharmazie., 2015;70(6):399-403.
• Carletto B., Berton J., Ferreira T.N., Favero G.M.: Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth. Article in Colloids and surfaces B: Biointerfaces, 2016;144:65-72 doi:10.1016/j.colsurfb.2016.04.001.
• Chachay V.S., Kirkpatrick C.M., Hickman I.J., Ferguson M., Prins J.B., Martin J.H.: Resveratrol-pills to replace a healthy diet? Br. J. Clin. Pharmacol., 2011;72(1):27- 38 doi:10.1111/j.1365-2125.2011.03966.x.
• Dani C., Oliboni L.S., Vanderlinde R., Bonatto D., Salvador M., Henriques J.A.: Phenolic content and antioxidant activities of white and purple juices manufactured with organically- or conventionally-produced grapes, Food Chem. Toxicol., 2007;45(12):2574-2580 doi:10.1016/j.fct.2007.06.022.
• Demoulin B., Hermant M., Castrogiovanni C., Staudt C., Dumont P.: Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis. Toxicol. In Vitro, 2015;29(5):1156-1165 doi:10.1016/j.tiv.2015.04.015.
• Dipak K.D., Maulik N.: Resveratrol in cardioprotection. A therapeutic promise of alternative medicine. Molecular Inventions, 2006;6(1):36-47 doi:10.1124/ mi.6.1.7.
• Dobrzyńska M.M.: Resveratrol as promising natural radioprotector. A review. Rocz Panstw Zakl Hig 2013;64(4):255-262.
• EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA): Safety of synthetic trans-resveratrol as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 2016;14(1):4368 [30 pp.] doi: 10.2903/j. efsa.2016.4368.
• Fernández-Mar M.I., Mateos R., García-Parrilla M.C., Puertas B., Cantos-Villar E.: Bioactive compounds in wine: Resveratrol, hydroxytyrosol and melatonin: A review. Food Chemistry, 2012;130(4):797-813.
• Fuggetta M.P., D’Atri S., Lanzilli G.; Tricarico M.; Cannavò E.; Zambruno G.; Falchetti R., Ravagnan G.: In vitro antitumour activity of resveratrol in human melanoma cells sensitive or resistant to temozolomide. Melanoma Research., 2004;14(3):189-196.
• Fulda S., Debatin K.M.: Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res., 2004;64(1):337-346.
• Gambini J., López-Grueso R., Olaso-González G., Inglés M., Abdelazid K., El Alami M., Bonet-Costa V., Borrás C., Vina J.: Resveratrol: distribución, propiedades y perspectivas. Rev. Esp. Geriatr. Gerontol., 2013;48(2):79-88 doi:10.1016/j.regg.2012.04.007.
• Ganapathy S., Chen Q., Singh K.P., Shankar S., Srivastava R.K.: Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLOS ONE, 2010;5(12):e15627-e15627 https://doi.org/10.1371/ journal.pone.0015627.
• Gao Q., Yuan Y., Gan H.Z., Peng Q.: Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis. Oncol. Lett., 2015;9(5):2381- 2387 doi:10.3892/ol.2015.2988.
• Gao S., Liu G-Z., Wang Z.: Modulation of Androgen Receptor-Dependent Transcription by Resveratroland Genistein in Prostate Cancer Cells. Prostate., 2004;59(2):214-225 doi:10.1002/pros.10375.
• Garvin S., Ollinger K, Dabrosin C.: Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett. 2006;231(1):113- 122 doi:10.1016/j.canlet.2005.01.031.
• Gehm B.D., McAndrews J.M., Chien P.Y., Jameson J.L.: Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA, 1997;94(25):14138-14143.
• Gibellini L., Bianchini E., De Biasi S., Nasi M., Cossarizza A., Pinti M.: Natural Compounds Modulating Mitochondrial Functions. Evid Based Complement Alternat. Med., 2015;2015:527209 doi: 10.1155/2015/527209.
• Hosseini A., Ghorbani A.: Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J. Phytomed., 2015;5(2):84-97 doi:10.22038/ AJP.2015.3872.
• Howells L. M., Berry D. P., Elliott P.J., Jacobson E.W., Hoffmann E., Hegarty B., Gescher A.J.: Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics. Cancer Prevention Research (Philadelphia, Pa.), 2011;4(9):1419-1425 doi:10.1158/1940-6207.CAPR- 11-0148.
• Hurst W.J., Glinski J.A., Miller K.B., Apgar J., Davey M.H., Stuart D.A.: Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products. J Agric. Food Chem., 2008;56(18):8374-8378 doi:10.1021/jf801297w.
• Jazirehi A.R., Bonavida B.: Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizesnon−Hodgkin’s lymphoma and multiple myeloma cell lines to paclitaxel – induced apoptosis. Mol. Cancer Ther., 2004;3(1):71-84.
• Ji Q., Liu X., Han Z., Zhou L., Sui H., Yan L., Jiang H., Ren J., Cai J., Li Q.: Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression. BMC Cancer. 2015;15(5):97 doi:10.1186/s12885-015-1119-y.
• Kalra N., Roy P., Prasad S., Shukla Y.: Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis. Life Sci. 2008;82(7-8):348- 358 doi:10.1016/j.lfs.2007.11.006.
• Kimura Y., Okuda H.: Effects of naturally occuring stilbene glucosides from medicinal plants and wine on tumor growth and lung metastasis in Lewis lung carcinoma bearing mice. J. Pharm. Pharmacol., 2000;52(10):1287-1295.
• Kopeć A., Piątkowska E., Leszczyńska T., Bieżanowska- Kopeć R.: Health stimulating properties of resveratrol. Food. Science. Technology. Quality, 2011;78(5):5-15 (in Polish).
• Kumar A., Dhar S., Rimando A.M., Lage J.M., Lewin J.R., Zhang X., Levenson A.S.: Epigenetic potential of resveratrol and analogs in preclinical models of prostate cancer. Ann. N. Y. Acad. Sci., 2015;1348(1):1- 9 doi:10.1111/nyas.12817.
• Laux M.T., Aregullin M., Berry J.P., Flanders J.A., Rodriguez E.: Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol. J. Altern. Complement Med., 2004;10(2):235-239 doi:10.1089/1076280041580387.
• Le Corre L., Fustier P., Chalabi N., Bignon Y.J., Bernard-Gallon D.: Effects of resveratrol on the expression of a panel of genes interacting with the BRCA1 oncosuppressor in human breast cell lines. Clin. Chim. Acta., 2004;344(1-2):115-121 doi:10.1016/j. cccn.2004.02.024.
• Lee S.S., Lee S.M., Kim M., Chun J., Cheong Y.K., Lee J.: Analysis of trans-resveratrol in peanuts and peanut butters consumed in Korea. Food Research International, 2004;37(3):247-251 doi:10.1016/j. foodres.2003.11.007.
• Li Z.G., Hong T., Shimada Y., Komoto I., Kawabe A., Ding Y., Kaganoi J., Hashimoto Y., Imamura M.: Supression of N-nitrosomethylbenzylamine (NMBA)- induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis, 2002;23(9):1531-1536.
• Lin H.C., Chen Y.F., Hsu W.H., Yang C.W., Kao C.H., Tsai T.F.: Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse model. Cancer Prev. Res. (Phila). 2012;5(7):952-962 doi:10.1158/1940-6207.CAPR-12-0001.
• Liontas A., Yeger H.: Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res., 2004;24(2B):987-998.
• Madadi N.R., Zong H., Ketkar A., Zheng C., Penthala N.R., Janganati V., Bommagani S., Eoff R.L., Guzman M.L., Crooks P.A.: Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm., 2015;6(3):788- 794 doi:10.1039/C4MD00478G.
• Malhotra A., Bath S., Elbarbry F.: An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol. Oxid. Med. Cell Longev., 2015;2015:803971 doi:10.1155/2015/803971.
• Maliszewska M.: Curcumin, indole-3-carbinol and resveratrol in chemoprevention of breast cancer. Postępy Fitoterapii, 2013;1:28-35 (in Polish).
• Medina-Bolivar F., Condori J., Rimando A.M., Hubstenberger J., Shelton K., O’Keefe S.F., Bennett S., Dolan M.C.: Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry, 2007;68(14):1992-2003 doi:10.1016/j. phytochem.2007.04.039.
• Mikstacka R., Ignatowicz E.: Chemopreventive and chemotherapeutic effect of trans-resveratrol and its analogues in cancer. Pol. Merk. Lek., 2010;28:496-500 (in Polish).
• Mikuła-Pietrasik J., Sosińska P., Murias M., Wierzchowski M., Brewińska-Olchowik M., Piwocka K., Szpurek D., Książek K.: High Potency of a Novel Resveratrol Derivative, 3,3’,4,4’-Tetrahydroxy-trans-stilbene, against Ovarian Cancer Is Associated with an Oxidative Stress-Mediated Imbalance between DNA Damage Accumulation and Repair. Oxid. Med. Cell Longev., 2015;2015:135691 doi:10.1155/2015/135691.
• Mróz P., Młynarczuk I.: TRIAL - apoptosis induction mechanisms and its employment in cancer therapy. Post. Biol. Kom., 2003; 30: 113-128 (in Polish).
• Mukherjee S., Dudley J.I., Das D.K.: Dose-dependency of resveratrol in providing health benefits. Dose-Response, 2010;8(4):478-500 doi:10.2203/dose-response.09-015. Mukherjee.
• Niles R.M., Rankin G.O.: Resveratrol, A Phytoalexin with a multitude of anti-cancer activities. W: Nutrition and cancer from epidemiology to biology. Red: Claudio P.P., Niles R.M., USA, 2012,3-14 doi:10.2174/978160 80544731120101.
• Opipari A.W. Jr., Tan L., Boitano A.E., Sorenson D.R., Aurora A., Liu J.R.: Resveratrol – induced autophagocytosis in ovarian cancer cells. Cancer Res., 2004;15,64(2):696- 703 doi:10.1158/0008-5472.CAN-03-240.
• Ortuño J.; Covas M.I.; Farre M.; Pujadas M.; Fito M.; Khymenets O.; Andres-Lacueva C.; Roset P.; Joglar J.; Lamuela-Raventós R.M.; de la Torre R.: Matrix effects on the bioavailability of resveratrol in humans. Food Chemistry. 2010;120(4):1123-1130 https://doi. org/10.1016/j.foodchem.2009.11.032.
• Patel K.R., Brown V.A., Jones D.J., Britton R.G., Hemingway D., Miller A.S., West K.P., Booth T.D., Perloff M., Crowell J.A., Brenner D.E., Steward W.P., Gescher A.J., Brown K.: Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res., 2010;70(19):7392-7399 doi:10.1158/0008-5472.CAN-10-2027.
• Patel K.R., Scott E., Brown V.A., Gescher A.J., Steward W.P., Brown K.: Clinical trials of resveratrol. Ann. N. Y. Acad. Sci., 2011;1215:161-169 doi:10.1111/j.1749- 6632.2010.05853.x.
• Pieszka M., Szczurek P., Ropka-Molik K., Oczkowicz M., Pieszka M.: The role of resveratrol in the regulation of cell metabolism--a review. Postepy Hig. Med. Dosw. (online), 2016;70:117-123 doi: 10.5604/17322693.1195844 (in Polish).
• Piver B., Fer M., Vitrae X., Merillon J.M., Dreano Y., Berthou F., Lucas D.: Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem. Pharmacol., 2004;68(4):773-782 doi: 10.1016/j.bcp.2004.05.008.
• Prasad K.: Resveratrol, Wine, and Atherosclerosis. Int. J. Angiol., 2012;21:7–18.
• Przysławski J., Dzięcioł M.: Resveratrol – current state of knowledge. Bromat. Chem. Toksykol., 2012;45:1166- 1174 (in Polish).
• Ragab A.S., Van Fleet J., Jankowski B., Park J.H., Bobzin S.C.: Detection and quantitation of resveratrol in tomato fruit (Lycopersicon esculentum Mill.). J. Agric. Food Chem. 2006;54:7175-7179.
• Ratan H.L., Steward W.P., Gescher A.J., Mellon J.K.: Resveratrol − a prostate cancer chemopreventive agent? Urol. Oncol., 2002;7:223-227.
• Rege S.D., Geetha T., Griffin G.D., Broderick T. L., Babu J.R.: Neuroprotective effects of resveratrol in Alzheimer disease pathology. Front Aging Neurosci. 2014;6:218 doi:10.3389/fnagi.2014.00218.
• Rimando A.M., Kalt W., Magee J.B., Dewey J., Ballington J.R.: Resveratrol, pterostilbene, and piceatannol in vaccinium berries. J. Agric. Food Chem., 2004;52(15):4713-4719 doi:10.1021/jf040095e.
• Saiko P., Szakmary A., Jaeger W., Szekeres T.: Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat. Res., 2008;658(1-2):68-94 doi:10.1016/j. mrrev.2007.08.004.
• Sebastià N., Montoro A., Mañes J., Soriano J.M.: A preliminary study of presence of resveratrol in skins and pulps of European and Japanese plum cultivars. J. Sci. Food Agric., 2012;92(15):3091-3094 doi:10.1002/ jsfa.5759.
• Seeni A., Takahashi S., Takeshita K., Tang M., Sugiura S., Sato S.Y., Shirai T.: Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac. J. Cancer. Prev., 2008;9(1):7-14.
• Selvaraj S., Sun Y., Sukumaran P., Singh B.B.: Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway. Mol. Carcinog. 2015;55(5):818-831 doi:10.1002/mc.22324.
• Sengottuvelan M., Deeptha K., Nalini N.: Resveratrol ameliorates DNA damage, prooxidant and antioxidant imbalance in 1,2-dimethylhydrazine induced rat colon carcinogenesis. Chem. Biol. Interact., 2009;181(2):193- 201 doi:10.1016/j.cbi.2009.06.004.
• Shi T., Liou L.S., Sadhukhan P., Duan Z.H., Novick A.C., Hissong J.G., Almasan A., DiDonato J.A.: Effects of Resveratrol on Gene Expression in Renal Cell Carcinoma. Cancer. Biol. Ther., 2004;3(9):882-888.
• Shrikanta A., Kumar A., Govindaswamy V.: Resveratrol content and antioxidant properties of underutilized fruits. J. Food Sci. Technol., 2015;52(1):383-390 doi:10.1007/s13197-013-0993-z.
• Shukla Y., Singh R.: Resveratrol and cellular mechanisms of cancer prevention. Ann. N. Y. Acad. Sci., 2011;1215:1-8 doi:10.1111/j.1749-6632.2010.05870.x.
• Siddiqui I.A., Sanna V., Ahmad N., Sechi M., Mukhtar H.: Resveratrol nanoformulation for cancer prevention and therapy. Ann. N. Y. Acad. Sci., 2015;1348(1):20-31 doi:10.1111/nyas.12811.
• Singh Ch.K., Ndiaye M.A., Ahmad N.: Resveratrol and cancer: Challenges for clinical translation. Biochim. Biophy.s Acta, 2015;1852(6):1178-1185 doi:10.1016/j. bbadis.2014.11.004.
• Smoliga J.M., Baur J.A., Hausenblas H.A.: Resveratrol and health-a comprehensive review of human clinical trials. Mol. Nutr. Food Res., 2011;55(8):1129-1141 doi:10.1002/mnfr.201100143.
• Tan L., Wang W., He G., Liu J.R.: Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer, 2015;122(5):722-729 doi:10.1002/cncr.29793.
• Todaro A., Palmeri R., Barbagallo R.N., Pifferi P.G., Spagna G.: Increase of trans-resveratrol in typical Sicilian wine using β-glucosidase from various sources. Food Chem., 2008;107:1570-1575.
• Tokuşoǧlu Ö., Ünal M. K., Yemiş F.: Determination of the phytoalexin resveratrol (3,5,4‘-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography−mass spectrometry (GC-MS). J. Agric. Food Chem., 2005;53(12):5003-5009 doi:10.1021/jf050496+.
• Troian S.A., Vicenzi K., Alves M.K: Content of resveratrol and total polyphenols in whole grape, reconstituted and sweetened juice sold in southern Brazil. Brazilian Journal of Food Research, 2016; 7 (1) DOI:10.3895/ rebrapa.v7n1.3506.
• Wang Q., Li H., Wang X.W., Wu D.C., Chen X.Y., Liu J.: Resveratrol promotes differentiation and induces Fas−independent apoptosis of human medulloblastoma cells. Neurosci Lett., 2003;351:83-86.
• Wang T.T., Schoene N.W., Kim Y.S., Mizuno C.S., Rimando A.M.: Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells. Mol. Nutr. Food Res., 2010;54(3):335-344 doi:10.1002/mnfr.200900143.
• Whitsett T.G, Carpenter D.M., Lamartiniere C.A.: Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats. J. Carcinog., 2006;5(15):15-24 doi:10.1186/1477-3163-5-15.
• Wolter F., Akoglu B., Clausnitzer A., Stein J.: Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. J Nutr., 2001,131(8):2197-2203.
• Xu Q., Zong L., Chen X., Jiang Z., Nan L., Li J., Duan W., Lei J., Zhang L., Ma J., Li X., Wang Z., Wu Z., Ma Q., Ma Z.: Resveratrol in the treatment of pancreatic cancer. Ann. N. Y. Acad. Sci., 2015;1348(1):10-19 doi:10.1111/nyas.12837.
• Yang J., Liu J., Lyu X., Fei S.: Resveratrol inhibits cell proliferation and up-regulates MICA/B expression in human colon cancer stem cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2015;31(7):889-893.
• Zdrojewicz Z., Belowska-Bień K.: Resveratrol – its activity and clinical role. Adv Clin. Exp. Med., 2005;14(5):1051-1056 (in Polish).
• Zhang L., Dai F., Sheng P.., Chen Z., Xu Q., Guo Y.: Resveratrol analogue 3,4,4′-trihydroxy-trans-stilbene induces apoptosis and autophagy in human non-small-cell lung cancer cells in vitro. Acta Pharmacol. Sin., 2015;36(10):1256-1265 doi:10.1038/aps.2015.46.
• Zhong L.X., Li H., Wu M.L., Liu X.Y., Zhong M.J., Chen X.Y., Liu J., Zhang Y.: Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells. J. Ovarian Res., 2015;8(25):25 doi:10.1186/s13048-015-0152-4.