Matrix metalloproteinase-2 C-1306T promoter polymorphism and breast cancer risk in the Saudi population

• Autorzy: Saeed H. M. , Alanazi M. S. , Alshahrani O. , Parine N. R. , Alabdulkarim H. A. , Shalaby M. A.
• Języki publikacji: EN

Abstrakty

EN

Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with susceptibility to breast cancer in the Saudi population. Ninety breast cancer patients and 92 age matched controls were included in this study. TaqMan Allele Discrimination assay and DNA sequencing techniques were used for genotyping. The results showed that, the frequency of MMP-2 CC wild genotype was lower in breast cancer patients when compared with healthy controls (0.65 versus 0.79). The homozygous CC (OR=2, χ2=5.36, p=0.02) and heterozygous CT (OR=1.98, χ2=4.1, p=0.04) showing significantly high risk of breast cancer in the investigated group. In conclusion our data suggest that the MMP-2 C-1306T polymorphism may be associated with increased breast cancer risk in the Saudi population.

Słowa kluczowe

EN

matrix metalloproteinase 2; enzyme; matrix protein; single nucleotide polymorphism; polymorphism; breast cancer; disease risk; cancer risk; Saudi Arabia; population

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 3
• Opis fizyczny: p.405-409,fig.,ref.

Twórcy

autor

Saeed H. M.

• Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

autor

Alanazi M. S.

• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

autor

Alshahrani O.

• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

autor

Parine N. R.

• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

autor

Alabdulkarim H. A.

• The Comprehensive Cancer Center at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia

autor

Shalaby M. A.

• Genetic Engineering and Biotechnology Research Institute (GEBRI), City for Scientific Research and Technology Applications, New Borg Alarab City, Alexandria, Egypt

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