Influence of the selected antibiotic on absorption process of Mg2+ ions from solid dispersions containing glutamate magnesium salts

• Autorzy: Marcoin W. , Szulc-Musiol B.
• Języki publikacji: EN

Abstrakty

EN

Numerous papers concerning the research on the role of magnesium in an organism and the effects of its deficiency indicate many causes and mechanisms leading to a negative balance of this macroelement. One of the causes of magnesium deficiency in systems may be its malabsorption from the digestive track resulting from taking compounds complexing magnesium ions or using drugs destructive to saprophytic flora. The results of our experiments testing in vitro the influence of β-lactam of penicillin G on the process of Mg2+ ions absorption through the intestinal membrane from solid dispersions containing phosphatidylcholine (PC 45) and the salts of magnesium glutamate and its derivatives from glycine and arginine ligands are presented in this paper. In order to make solid dispersions containing glutamate magnesium salts, auxiliary substances, polyvinylpyrrolidone (PVP) and phosphatidylcholine (PC45), were used. For the solid dispersions obtained by the Hansch method, partition coefficient in the system n - octanol/phosphate buffer was determined. Log P was calculated for the examined dispersions. Research on the degree of absorption of Mg2+ ions solid dispersions, which was the subject of the experiment, was done by the in vitro method, making use of a model of the intestine (ileum) of a rat. The evaluation of penicillin G influence on the degree of absorption of Mg2+ ions from solid dispersions containing magnesium salts was carried out by the above method. The results of experiments indicate that an additional ligand (glycine, arginine) in the structure of magnesium glutamate particle significantly influences the change of the value of of the kinetic absorption parameter of Mg2+ ions from solid dispersions containing magnesium salts. Introducing an additional ligand induces an accelerated rate of diffusion of the examined salts through the intestine. It has been found that penicillin G hinders the degree of Mg2+ ions absorption of the examined solid dispersions in the small intestine.

• Wydawca: -
• Czasopismo: Journal of Elementology
• Rocznik: 2015
• Tom: 20
• Numer: 1
• Opis fizyczny: p.177-184,fig.,ref.

Twórcy

autor

Marcoin W.

• Silesian College of Medicine in Katowice, A.Mickiewicza 29, 40-085 Katowice, Poland

autor

Szulc-Musiol B.

• Chair of Applied Pharmacy, Medical University of Silesia in Katowice, Katowice, Poland

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Identyfikatory

DOI

10.5601/jelem.2013.18.4.520