Response of porcine oocytes exposed to testosterone and substance P in vitro

• Autorzy: Winiarczyk D. , Bobrowiec R. , Kosior-Korzecka U. , Witkowska K. , Radwanska P.
• Języki publikacji: EN

Abstrakty

EN

The overproduction of androgens during the course of foliculogenesis may lead to disturbances in ovulation – the main reason for the establishment of the pathological state known as polycystic ovarian syndrome (PCOS). Furthermore, recently attention has been drawn to the involvement of tachykinins such as substance P (SP) in this process. Apart from this, both in animals and women, the above factors may impair oocyte development. Taking into account the aforementioned data we sought to find and compare the response of isolated porcine oocytes to different doses of testosterone (T) and SP with the goal of clarifying their effect on oocyte growth and meiosis progress. In our experimental approach porcine oocytes were exposed to these factors for 4 h, 20 h or 44 h of culture. The obtained results reveal that both T and SP inhibit growth of porcine oocytes, cumulus cell expansion and meiotic resumption in vitro. Our data show that the inhibitory effect of SP on porcine oocytes is far weaker than the impact of T.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2017
• Tom: 73
• Numer: 01
• Opis fizyczny: p.28-32,fig.,ref.

Twórcy

autor

Winiarczyk D.

• Department of Experimental Embryology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postepu 36A, Jastrzebiec, 05-552 Magdalenka, Poland
• Chair of Preclinical Veterinary Sciences, Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033, Lublin, Poland

autor

Bobrowiec R.

• Chair of Preclinical Veterinary Sciences, Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033, Lublin, Poland

autor

Kosior-Korzecka U.

• Chair of Preclinical Veterinary Sciences, Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033, Lublin, Poland

autor

Witkowska K.

• Chair of Preclinical Veterinary Sciences, Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033, Lublin, Poland

autor

Radwanska P.

• Chair of Preclinical Veterinary Sciences, Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033, Lublin, Poland

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Identyfikatory

DOI

10.21521/mw.5627