Biomarkers in canine inflammatory bowel disease diagnostics

• Autorzy: Wdowiak M. , Rychlik A. , Kolodziejska-Sawerska A.
• Języki publikacji: EN

Abstrakty

EN

Canine inflammatory bowel disease (IBD) is a heterogeneous group of chronic gastrointestinal disorders. The etiology, similar to human IBD, remains unknown. Canine IBD is diagnosed by exclusion, which is a long, time and money-consuming process due to the need of elimination of other diseases presenting with similar symptoms. Therefore, a search for a specific and sensitive marker is needed to overcome these difficulties. The article is divided into 3 sections presenting up-to-date information about laboratory markers, immunohistochemical markers and changes in the neurochemical coding of the enteric nervous system, concentrating on their usefulness and future applications. Data concerning laboratory and immunohistochemical markers is based mainly on canine IBD, while the neuroimmunohistochemistry section presents knowledge from human IBD due to the lack of such studies in veterinary medicine.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2013
• Tom: 16
• Numer: 3
• Opis fizyczny: p.601-610,ref.

Twórcy

autor

Wdowiak M.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Rychlik A.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland

autor

Kolodziejska-Sawerska A.

• Department of Clinical Diagnostics, Faculty of Veterinary Medicine University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland

Bibliografia

• Allenspach K, Luckschander N, Styner M, Seibold F, Doherr M, Aeschbach D, Gaschen F (2004) Evaluation of assays for perinuclear antineutrophilic cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in dogs with inflammatory bowel disease. Am J Vet Res 65: 1279-1283.
• Allenspach K, Bergman PJ, Sauter S, Gröne A, Doherr MG, Gaschen F (2006) P-glycoprotein expression in lamina propria lymphocytes of duodenal biopsy samples in dogs with chronic idiopathic enteropathies. J Comp Pathol 134: 1-7.
• Arranz A, Abad C, Juarranz Y, Leceta J, Martinez C, Gomariz RP (2008) Vasoactive intestinal peptide as a healing mediator in Crohn’s disease. Neuroimmunomodulation 15: 46-53.
• Batt R (2000) Update on the non-invasive monitoring of intestinal disease in dogs and cats. Revue de Médecine Vétérinaire 151: 559-563.
• Belai A, Boulos PB, Robson T, Burnstock G (1997) Neurochemical coding in the small intestine of patients with Crohn’s disease. Gut 40: 767-774.
• Benya RV, Matkowskyj KA, Danilkovich A, Hecht G (1998) Galanin causes Cl- secretion in the human colon. Potential significance of inflammation-associated NF-kappa B activation on galanin-1 receptor expression and function. Ann N Y Acad Sci 863: 64-77.
• van Bergeijk JD, Wilson JH (1997) Somatostatin in inflammatory bowel disease. Mediators Inflamm 6: 303-309.
• Berghoff N, Steiner JM (2011) Laboratory tests for the diagnosis and management of chronic canine and feline enteropathies. Vet Clin North Am Small Anim Pract 41: 311-328.
• Burgener IA, König A, Allenspach K, Sauter SN, Boisclair J, Doherr MG, Jungi TW (2008) Upregulation of toll-like receptors in chronic enteropathies in dogs. J Vet Intern Med 22: 553-560.
• Bernstein CN, Robert ME, Eysselein VE (1993) Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. Am J Gastroenterol 88: 908-913.
• Cerun JJ, Eckersall PD, Martinez-Subiela S (2005) Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol 34: 85-99.
• Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL (2004) Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126: 1657-1664.
• Collins SM, Blennerhassett P, Vermillion DL, Davis K, Langer J, Ernst PB (1992) Impaired acetylocholine release in the inflamed rat intestine is T cell independent. Am J Physiol 263: G198-G201.
• Dandrieux JR, Bornand VF, Doherr MG, Kano R, Zurbriggen A, Burgener IA (2008) Evaluation of lymphocyte apoptosis in dogs with inflammatory bowel disease. Am J Vet Res 69: 1279-1285.
• Geboes K, Collins S (1998) Structural abnormalities of the nervous system in Crohn’s disease and ulcerative colitis. Neurogastroenterol Motil 10: 189-202.
• German AJ, Hall EJ, Kelly DF, Watson AD, Day MJ (2000) An immunohistochemical study of histiocytic ulcerative colitis in boxer dogs. J Comp Pathol 122: 163-175.
• German AJ, Hall EJ, Day MJ (2001) Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med 15: 14-25.
• Goldin E, Karmeli F, Selinger Z, Rachmilewitz D (1989) Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation. Dig Dis Sci 34: 754-757.
• Gross KJ, Pothoulakis C (2007) Role of neuropeptides in inflammatory bowel disease. Inflamm Bowel Dis 13: 918-932.
• Heilmann RM, Suchodolski JS, Steiner JM (2008) Development and analytic validation of a radioimmunoassay for the quantification of canine calprotectin in serum and feces from dogs. Am j Vet Res 69: 845-853.
• Heilmann RM, Jergens AE, Ackermann MR, Barr JW, Suchodolski JS, Steiner JM (2012) Serum calprotectin concentrations in dogs with idiopathic inflammatory bowel disease. Am J Vet Res 73: 1900-1907.
• Holzer P (1998) Implications of tachykinins and calcitonin gene-related peptide in inflammatory bowel disease. Digestion 59: 269-283.
• Im Hof M, Schnyder M, Hartnack S, Stanke-Labesque F, Luckschander N, Burgener IA (2012) Urinary leukotriene E4 concentrations as a potential marker of inflammation in dogs with inflammatory bowel disease. J Vet Intern Med 26: 269-274.
• Jergens AE, Moore FM, Kaiser MS, Haynes JS, Kinyon JM (1996) Morphometric evaluation of immunoglobulin A – containing and immunoglobulin G-containing cells and T cells in duodenal mucosa from healthy dogs and from dogs with inflammatory bowel disease or nonspecific gastroenteritis. Am J Vet Res 57: 697- 704.
• Jergens AE (1999a) Inflammatory bowel disease. Current perspectives. Vet Clin North Am Small Anim Pract 29: 501-521.
• Jergens AE, Gamet Y, Moore FM, Niyo Y, Tsao C, Smith B (1999b) Colonic lymphocyte and plasma cell populations in dogs with lymphocytic-plasmacytic colitis. Am J Vet Res 60: 515-520.
• Jergens AE, Schreiner CA, Frank DE, Niyo Y, Ahrens FE, Eckersall PD, Benson TJ, Evans R (2003) A Scoring Index for Disease Activity in Canine Inflammatory Bowel Disease. J Vet Intern Med 17: 291-297.
• Jergens AE, Simpson KW (2012) Inflammatory bowel disease in veterinary medicine. Front Biosci (Elite Ed) 4: 1404-1419.
• Kathrani A, Schmitz S, Priestnall SL, Smith KC, Werling D, Garden OA, Allenspach K (2011) CD11c+ Cells are significantly decreased in the duodenum, ileum and colon of dogs with inflammatory bowel disease. J Comp Pathol 145: 359-366.
• Keranen U, Kiviluoto T, Jarvinen H, Back N, Kivilaakso E, Soinila S (1995) Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis. Dig Dis Sci 40: 2250-2258.
• Kimura M, Masuda T, Hiwatashi N, Toyota T, Nagura H (1994) Changes in neuropeptide-containing nerves in human colonic mucosa with inflammatory bowel disease. Pathol Int 44: 624-634.
• Kleinschmidt S, Nolte I, Hewicker-Trautwein M (2011) Structural and functional changes of neuronal and glial components of the feline enteric nervous system in cats with chronic inflammatory and non-inflammatory diseases of the gastrointestinal tract. Res Vet Sci 91: e129-135.
• Koch TR, Carney JA, Go VL (1987) Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases. Dig Dis Sci 32: 369-376.
• Koch TR, Carney JA, Morris VA, Go VL (1988) Somatostatin in the idiopathic inflammatory bowel diseases. Dis Colon Rectum 31: 198-203.
• Kubota Y, Petras RE, Ottaway CA, Tubbs RR, Farmer RG, Fiocchi C (1992) Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease. Gastroenterology 102: 1242:1251.
• Lakhan SE, Kirchgessner A (2010) Neuroinflammation in inflammatory bowel disease. J Neuroinflammation 7: 37.
• Lee CM, Kumar RK, Lubowski DZ, Burcher E (2002) Neuropeptides and nerve growth in inflammatory bowel diseases: a quantitative immunohistochemical study. Dig Dis Sci 47: 495- 502.
• Lomax AE, Fernández E, Sharkey KA (2005) Plasticity oft he enteric nervous system during intestinal inflammation. Neurogastroenterol Motil 17: 4-15.
• Luckschander N, Allenspach K, Hall J, Seibold F, Grone A, Doherr MG, Gaschen F (2006) Perinuclear antineutrophilic cytoplasmic antibody and response to treatment in diarrheic dogs with food responsive disease or inflammatory bowel disease. J Vet Intern Med 20: 221-227.
• Luckschander N, Hall JA, Gaschen F, Forster U, Wenzlow N, Hermann P, Allenspach K, Dobbelaere D, Burgener IA, Welle M (2010) Activation of nuclear factor – κB in dogs with chronic entheropathies. Vet Immunol Immunopathol 133: 228-236.
• Mancho C, Sainz Á, Garcta-Sancho M, Villaescusa A, Tesouro MA, Rodríguez-Franco F (z 2010) Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease. J Vet Diagn Invest 22: 553-558.
• Manolakis AC, Kapsoritakis AN, Georgoulias P, Tzavara C, Valotassiou V, Kapsoritaki A, Potamianos SP (2010) Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome. BMC Gastroeneterol 10: 118.
• Mazumdar S, Das KM (1992) Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease. Am J Gastroenterol 87: 176-181.
• McCann TM, Ridyard AE, Else RW, Simpson JW (2007) Evaluation of disease activity markers in dogs with idiopathic inflammatory bowel disease. J Small Anim Pract 48: 620-625.
• McMahon LA, House AK, Catchpole B, Elson-Riggins J, Riddle A, Smith K, Werling D, Burgener IA, Allenspach K (2010) Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease. Vet Immunol Immunopathol 135: 158-163.
• Murphy KF, German AJ, Ruaux CG, Steiner JM, Williams DA, Hall EJ (2003) Fecal α1 – Proteinase Inhibitor Concentration in Dogs with Chronic Gastrointestinal Disease. Vet Clin Pathol 32: 67-72.
• Nakamura RM, Matsutani M, Barry M (2003) Advances in clinical laboratory tests for inflammatory bowel disease. Clin Chim Acta 335: 9-20.
• Neubauer K, Dudkowiak R (2010) Fecal markers in inflammatory bowel disease. Adv Clin Exp Med 19: 251-255.
• Neunlist M, Aubert P, Toquet C, Oreshkova T, Barouk J, Lehur PA, Schemann M, Galmiche JP (2003) Changes in chemical coding of myenteric neurones in ulcerative colitis. Gut 52: 84-90.
• O’Morain C, Bishop AE, McGregor GP, Levi AJ, Blomm SR, Polak JM, Peters TJ (1984) Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease. Gut 25: 57-61.
• Reinshagen M, Egger N, Procaccino F, Eysselein VE (1997) Neuropeptides in inflammatory bowel disease: an update. Inflamm Bowel Dis 3: 303-313.
• Sandborn WJ (2004) Serologic markers in inflammatory bowel disease: state of the art. Rev Gastroenterol Disord 4: 167-174.
• Schneider J, Jehle EC, Starlinger MJ, Neunlist M, Michel K, Hoppe S, Schemann M (2001) Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn’s disease. Neurogastroenterol Motil 13: 255-264.
• Simpson KW, Jergens AE (2011) Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet Clin North Am Small Anim Pract 41: 381-398.
• Stonehewer J, Simpson JW, Else RW, Macintyre N (1998) Evaluation of B and T lymphocytes and plasma cells in colonic mucosa from healthy dogs and from dogs with inflammatory bowel disease. Res Vet Sci 65: 59-63.
• Taylor CT, Keely SJ (2007) The autonomic nervous system and inflammatory bowel disease. Auton Neurosci 133: 104-114.
• Vieira A, Fang CB, Rolim EG, Klug WA, Steinwurz F, Rossini LG, Candelária PA (2009) Inflammatory bowel disease activity assessed by fecal calprotectin and lactoferrin: correlation with laboratory parameters, clinical, endoscopic and histological indexes. BMC Res Notes 2: 221.
• Willard MD, Jergens AE, Duncan RB, Leib MS, McCracken MD, DeNovo RC, Helman RG, Slater MR, Harbison JL (2002) Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats. J Am Vet Med Assoc 220: 1177-1182.
• Winterkamp S, Weidenhiller M, Otte P, Stolper J, Schwab D, Hahn EG, Raithel M (2002) Urinary excretion of N-metylhistamine as a marker of disease activity in inflammatory bowel disease. Am J Gastroenterol 97: 3071-7.
• Yamamoto H, Morise K, Kusugami K, Furusawa A, Konagaya T, Nishio Y, Kaneko H, Uchida K, Nagai H, Mitsuma T, Nagura H (1996) Abnormal neuropeptide concentration in rectal mucosa of patients with inflammatory bowel disease. J Gastroenterol 31: 525-532.