Inactivation of the GluN1 subunit of the NMDA receptor modifies functions of dopaminoceptive neurons in the rat nucleus accumbens

• Autorzy: Sowa J. , Bobula B. , Tokarski K. , Rodriguez-Parkitna J. , Przewlocki R. , Hess G.
• Języki publikacji: EN

Abstrakty

EN

Adaptive behavior, such as regulation of appetitive motivation or reward processing, is associated with plasticity of the brain’s dopamine system. We examined different types of adaptive behavior in the transgenic mouse line (NR1D1CreERT2) where the GluN1 subunit is selectively inactivated in dopaminoceptive neurons. We used electrophysiological recordings to investigate if functions of D1-expressing neurons are modified. In transgenic animals the amplitude of field potentials in the NAcc was not different form controls, however, LTP was reduced from 138% in control to 118% in D1ERT2 [Tg-N/0-N] animals. Recordings of spontaneous EPSCs from medium spiny neurons of the NAcc demonstrated that approximately 50% of the cells lacked the NMDAR-dependent component of sEPSCs. These results suggest that the mutation significantly alters functions of dopaminoceptive neurons.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.334

Twórcy

autor

Sowa J.

• Department of Physiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Bobula B.

• Department of Physiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Tokarski K.

• Department of Physiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Rodriguez-Parkitna J.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Przewlocki R.

• Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Hess G.

• Department of Physiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland