Arbutin production in Ruta graveolens L. and Hypericum perforatum L. in vitro cultures

• Autorzy: Piekoszewska A. , Ekiert H. , Zubek S.
• Języki publikacji: EN

Abstrakty

EN

Optimization of conditions for hydroquinone biotransformation into its β-ᴅ-glucoside, arbutin, in agitated shoot cultures of Ruta graveolens L. and Hypericum perforatum L. allowed us to obtain a maximum content of this important therapeutic and cosmetic product of 7.8 and 7.2% (dry weight), respectively. These contents are higher than respective values required for standardization of known arbutin-containing plant raw materials according to the European Pharmacopoeia and national pharmacopoeias of European countries.

Słowa kluczowe

EN

arbutin; Ruta graveolens; Hypericum perforatum; in vitro culture; shoot culture; biotransformation; beta-D-glucosylation; hydroquinone; St.John's wort

• Wydawca: -
• Czasopismo: Acta Physiologiae Plantarum
• Rocznik: 2010
• Tom: 32
• Numer: 2
• Opis fizyczny: p.223-229,fig.,ref.

Twórcy

autor

Piekoszewska A.

• Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna St., 30-688 Krakow, Poland

autor

Ekiert H.

• Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna St., 30-688 Krakow, Poland

autor

Zubek S.

• Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna St., 30-688 Krakow, Poland

Bibliografia

• Akiu S, Suzuki Y, Fujinuma Y, Asahara T, Fukuda M (1988) Inhibitory effect of arbutin on melanogenesis: biochemical study in cultured B16 melanoma cells and effect on the UV-induced pigmentation in human skin. Proc Jpn Soc Invest Dermatol 12:138–139
• Barnes J, Anderson LA, Philipson JD (2007) Herbal medicines, 3rd edn. Pharmaceutical Press, London, Chicago pp 577–579
• Bergier K, Polaszczyk B, Wielanek M, Gajewska E, Królicka A, Skłodowska M (2007) Arbutin formation by hairy roots of Physalis ixocarpa treated with hydroquinone. In: 7th International conference on eco-physiological aspects of plant responses to stress factors, Cracow, Poland, p 39
• Dušková J, Jahodář L, Dušek J (1994) Neue Möglichkeiten der Produktion von Arbutin durch Gewebekulturen. Pharmazie 49:624
• Dušková J, Dušek J, Jahodář L (1999) Zur Biotransformation von Hydrochinon zu Arbutin in den In Vitro-Kulturen. Herba Pol 45:23–26
• Dušková J, Dušek J, Jahodář L, Poustka F (2005) Arbutin, salicin: the possibilities of their biotechnological production. Cesk Slov Farm 54:78–81
• Ekiert H (2004) Accumulation of biologically active furanocoumarins within in vitro cultures of medicinal plants. In: Ramawat KG (ed) Biotechnology of medicinal plants. Vitalizer and therapeutic. Science Publishers, Enfield, New Hampshire, pp 267–296
• Ekiert H, Czygan F-Ch (2005) Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L and Ruta graveolens ssp. divaricata (Tenore) Gams. Pharmazie 60:623–626
• Ekiert H, Czygan F-Ch (2007) Secondary metabolites in in vitro cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. In: Ramawat KG, Merillon JM (eds) Biotechnology. Secondary Metabolites. Plants and Microbes, 2nd edn edn. Science Publishers, Enfield, Plymouth, pp 445–482
• Ekiert H, Chołoniewska M, Gomółka E (2001) Accumulation of furanocoumarins in Ruta graveolens L. shoot culture. Biotechnol Lett 23:543–545
• Ekiert H, Szewczyk A, Kuś A (2009) Free phenolic acids in Ruta graveolens L. in vitro culture. Pharmazie 64:694–696
• European Pharmacopoeia (2008) Council of Europe, 6th edn, vol 2, Strasburg
• Farmakopea Polska VI (Polish Pharmacopoeia 6th edn) (2002) P.T.Farm, Warszawa
• Farmakopea Polska VIII (Polish Pharmacopoeia 8th edn) (2008) P.T.Farm, Warszawa
• Kittipongpatana N, Maneerat P, Pattanakitkosol P, Kittipongpatana OS (2007a) Effect of some factors on the growth of Capsicum annuum L. cell suspension culture and biotransformation of hydroquinone to arbutin. CMU J Nat Sci 6:207–218
• Kittipongpatana N, Theeraphong T, Srimanee A, Kittipongpatana OS (2007b) Biotransformation of hydroquinone to arbutin by cell-suspension cultures of three Thai Solanaceous plants. CMU J Nat Sci 6:219–229
• Kurosu J, Sato T, Yoshida K, Tsugane T, Shimura S, Kirimura K, Kino K, Usami S (2002) Enzymatic synthesis of α-arbutin by α-anomer-selective glucosylation of hydroquinone using lyophilized cells of Xanthomonas campestris WU-9701. J Biosci Bioeng 3:328–330
• Linsmaier EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18:100–127
• Lutterbach R, Stöckigt J (1992) High yield formation of arbutin from hydroquinone by cell-suspension cultures of Rauvolfia serpentina. Helv Chim Acta 75:2009–2011
• Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–497
• Skrzypczak-Pietraszek E, Szewczyk A, Piekoszewska A, Ekiert H (2005) Biotransformation of hydroquinone to arbutin in plant in vitro cultures—preliminary results. Acta Physiol Plant 27:79–87
• Štambergová A, Supčiková M, Leifertová I (1985) Hodnoceni fenolických lŕtek v Arctostaphylos uva-ursi. IV. Stanoveni arbutinu, metylarbutinu a hydrochinonu v listech metodou HPLC. Českoslov Farm 34:179–182
• Stammwitz U (1998) Pflanzliche Harnwegsdesinfizienzien—heute noch aktuell? Z Phytother 19:90–95
• Strapková A, Jahodář L, Nosalová G (1991) Antitussive effect of arbutin. Pharmazie 46:611–612
• Suzuki T, Yoshioka T, Tabata M, Fujita Y (1987) Potential of Datura innoxia cell suspension cultures for glycosylating hydroquinone. Plant Cell Rep 6:275–278
• Wichtl M (1997) Teedrogen und Phytopharmaka. Wissenschaftliche Verlagsgesellschaft mbH., Stuttgart, pp 599–602
• Yokoyama M, Inomata S (1998) Catharanthus roseus (Periwinkle): in vitro culture and high-level production of arbutin by biotransformation. In: Bajaj YPS (ed) Biotechnology in agriculture and forestry. Medicinal and aromatic plants X, vol 41. Springer, Berlin, Heidelberg, New York, pp 67–80