Leonurus cardiaca L.herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis

• Autorzy: Micota B. , Sadowska B. , Podsedek A. , Redzynia M. , Rozalska B.
• Języki publikacji: EN

Abstrakty

EN

 The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2014
• Tom: 61
• Numer: 2
• Opis fizyczny: p.385-388,fig.,ref.

Twórcy

autor

Micota B.

• Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Lodz, Poland

autor

Sadowska B.

• Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Lodz, Poland

autor

Podsedek A.

• Institute of Technical Biochemistry, Department of Biotechnology and Food Sciences Lodz Technical University, Poland, Lodz, Poland

autor

Redzynia M.

• Institute of Technical Biochemistry, Department of Biotechnology and Food Sciences Lodz Technical University, Poland, Lodz, Poland

autor

Rozalska B.

• Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Lodz, Poland

Bibliografia

• Anderson MJ, Lin YC, Gillman AN, Parks PJ, Schlievert PM, Peterson ML (2012) Alpha-toxin promotes Staphylococcus aureus mucosal biofilm formation. Front Cell Infect Microbiol 2: 64-10. 
• Chavakis T, Wiechmann K, Preissner KT, Herrmann M (2005) Staphylococcus aureus interactions with the endothelium. Thromb Haemost 94: 278-285. 
• Checker R, Sandur SK, Sharma D, Patwardhan RS, Jayakumar S, Kohli V, Sethi V, Aggarwal BB, Sainis KB (2012) Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. PLoS 7: e31318. 
• Clinical and Laboratory Standards Institute (2009) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M07-A8, Wayne, USA, 8th edn, 29: 5-36. 
• Edwards AM, Massey RC (2011) How does Staphylococcus aureus escape the bloodstream. Trends Microbiol 19: 184-190. 
• Fraga CG, Galleano M, Verstraeten SV, Oteiza PI (2010) Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 31: 435-445. 
• Hauck CR, Ohlsen K (2006) Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus. Curr Opin Microbiol 9: 5-11. 
• Kim HK, Thammavongsa V, Schneewind O, Missiakas D (2012) Recurrent infections and immune evasion strategies of Staphylococcus aureus. Curr Opin Microbiol 15: 92-99. 
• McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM (2011) Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog 7: e1002307. 
• McAdow M, Missiakas DM, Schneewind O (2012) Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun 4: 141-148. 
• Sadowska B (2010) The virulence factor of planktonic and biofilm Staphylococcus aureus forms - the inteference with leukocytes activity, pp 1-287. Piktor Press, Lodz, Poland (In Polish).
• Saw JT, Bahari MB, Ang HH, Lim YH (2006) Potential drug-herb interaction with antiplatelet/anticoagulant drugs. Complement Ther Clin Pract 12: 236-241. 
• Widmer E, Que YA, Entenza JM, Moreillon P (2006) New concepts in the pathophysiology of infective endocarditis. Curr Infect Dis Rep 8: 271-279. 
• Wojtyniak K, Szymański M, Matławska I (2013) Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 27: 1115-1120. 
• Zhang X, Liu Y, Gao Y, Dong J, Mu C, Lu Q, Shao N, Yang G (2011) Inhibiting platelets aggregation could aggravate the acute infection caused by Staphylococcus aureus. Platelets 22: 228-236.