Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons

• Autorzy: Sureshkumar S. , Balachandar V. , Devi S. M. , Arun M. , Karthickkumar A. , Balamuralikrishnan B. , Sankar K. , Mustaqahamed S. A. K. , Dharwadkar S. N. , Sasikala K. , Cho S.-G.
• Języki publikacji: EN

Abstrakty

EN

Polycyclic aromatic hydrocarbons (PAHs) result from the incomplete combustion of natural or synthetic organic materials. The working environment at a coke plant can negatively affect the employed workers who were exposed to coke oven emissions containing PAHs, which formed and released into the environment by the process of pyrolysis of coke. This study aims to analyze the relationship between the exposure of PAHs and the risk of genetic damages such as chromosomal alteration (CA), micronucleus (MN), and DNA damage (PCR-RFLP) in peripheral blood lymphocytes of 27 coke oven workers and equal number of control subjects. The exposed subjects and controls were divided into two groups based on their age (group I<35 years and group II ≥35 years). The exposed subjects were further classified into two groups based on the exposure period (<12 years and ≥12 years). The frequencies of CA and MN in exposed subjects are relatively high with respect to controls. The XRCC1 399 Arg/gln polymorphism showed a substantial smaller difference in allele frequencies between exposed and control subjects. Based on present data, it was concluded that coke oven workers under risk should be monitored for adverse effects of the any long-term exposure.

Słowa kluczowe

EN

cytogenetic risk; worker; exposure; polycyclic aromatic hydrocarbon; chromosomal aberration; micronucleus

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 3
• Opis fizyczny: p.375-379,ref.

Twórcy

autor

Sureshkumar S.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Balachandar V.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Devi S. M.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Arun M.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Karthickkumar A.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Balamuralikrishnan B.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Sankar K.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Mustaqahamed S. A. K.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Dharwadkar S. N.

• KLES S-Nijalingappa College, KLE Medical University, Bangalore, Karnataka, India

autor

Sasikala K.

• Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India

autor

Cho S.-G.

• Molecular Cell Biology and Stem Cell Laboratory, Department of Animal Biotechnology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, Korea

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