Up-regulation of cochlear Hes1 expression in response to noise exposure

• Autorzy: Wang B. , Liu Y. , Zhu X. , Chi F. , Zhang Y. , Yang M.
• Języki publikacji: EN

Abstrakty

EN

Hes l, a hairy and enhancer of split homolog, negatively regulates inner ear hair cell differentiation. The main objective of this study was to investigate the status of the Hes l gene in the noise-damaged cochlea in relation to the degree of noise-induced hearing loss (NIHL). Adult albino guinea pigs were exposed to white-band noise (115 dB sound pressure level). Noise exposure for either 1 or hours induced significant elevations of threshold in auditory brainstem response (ABR) compared with unexposed controls. Succinate dehydrogenase staining showed that white-band noise exposure caused significant outer hair cell losses. In addition, we found significant up-regulations of cochlear Hesl mRNA and protein expressions following acoustic trauma, and Hesl mRNA expression was positively correlated with NIHL. These findings suggest that up-regulation of Hes l expression in response to noise exposure may be one of the underlying mechanisms of NIHL.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 2
• Opis fizyczny: p.256-262,fig.,ref.

Twórcy

autor

Wang B.

• Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, P.R. China
• Department of Physiology, Second Military Medical University, Shanghai, P.R. China

autor

Liu Y.

• Department of Pathophysiology, Second Military Medical University, Shanghai, P.R. China

autor

Zhu X.

• Department of Physiology, Second Military Medical University, Shanghai, P.R. China

autor

Chi F.

• Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, P.R. China

autor

Zhang Y.

• Department of Physiology, Second Military Medical University, Shanghai, P.R. China

autor

Yang M.

• Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, P.R. China

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