Theoretical model explaining the relationship between the molecular mass and the activation energy of the enzyme revealed by a large-scale analysis of bioinformatics data

• Autorzy: Pawlowski P. H. , Zielenkiewicz P.
• Języki publikacji: EN

Abstrakty

EN

 A general dependence of the enzyme catalytic rate on its mass was revealed when a statistical analysis of 17065 records from the EMP database was performed. The estimated activation energy of the catalytic process decreases asymptotically with the enzyme molecular mass increase. The proposed theoretical model postulates the existence of an intermediate complex of the enzyme and the departing product. It allows for the explanation of the discovered mass-energy relationship, as an effect of the global enzyme-product interactions during complex dissociation. Fitted parameters of the model seem to be in agreement with those widely accepted for the van der Waals energy of molecular interactions. Their values also agree with the picture of the hydrogen bonding in the catalytic process and suggest that surface walk can be the favorable way of the product departure.

Słowa kluczowe

EN

theoretical model; relationship; molecular mass; activation energy; enzyme; catalysis; bioinformatics; statistics

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 2
• Opis fizyczny: p.239-247,fig.,ref.

Twórcy

autor

Pawlowski P. H.

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

autor

Zielenkiewicz P.

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

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