Study of antiurolithiatic activity of a formulated herbal suspension

• Autorzy: Saxena N. , Argal A.

Warianty tytułu

PL

Badania nad działaniem mieszanki ziołowej w kamicy nerkowej

• Języki publikacji: EN

Abstrakty

EN

Urolithiasis is the process of formation of stone in the urinary tract by crystal nucleation, aggregation and retention in the urinary tract. Traditional medicinal plants have been successfully used to overcome urolithiasis. Hence, herbal formulation containing a mixture of plant extracts was prepared and evaluated for the antiurolithiatic activity. This formulation contained alcoholic extracts of fruit of Tribulus terrestris, root of Boerhavia diffusa and leaves of Azadirachta indica Studies were performed in ethylene glycol-induced urolithiasis model using Cystone as a standard drug. Ethylene glycol increases the level of calcium, oxalate and phosphate which are responsible for urolithiasis. The herbal suspension decreased the level of calcium, oxalate and phosphate significantly at doses of 200 and 300 mg/kg when compared to the negative control group. Creatine, uric acid and urea were also decreased significantly at all dose levels. Histopathology has supported these results. The level of LD50 was found to be higher than 2000 mg/kg. Therefore, the prepared formulation has appreciable significant antiurolithiatic activity and is safe for use.

PL

Kamica nerkowa to proces polegający na tworzeniu, agregacji i odkładaniu się kryształów w układzie moczowym. Do przeciwdziałania kamicy nerkowej z powodzeniem stosuje się tradycyjne zioła. W przedstawionej pracy przygotowano mieszankę ziołową zawierającą wyciągi roślinne i zbadano jej właściwości hamujące rozwój kamicy. W skład mieszanki wchodziły wyciągi alkoholowe z owoców Tribulus terrestris, korzeni Boerhavia diffusa oraz liści Azadirachta indica. Badanie przeprowadzono na modelu kamicy nerkowej indukowanej glikolem etylenowym, stosując jako kontrolę standardowy lek Cystone. Glikol etylenowy podnosi poziom wapnia, szczawianów i fosforanów, które są odpowiedzialne za rozwój kamicy. Zastosowanie mieszanki ziołowej (w dawce 200 i 300 mg/kg) istotnie obniżyło poziom wapnia, szczawianów i fosforanów w porównaniu z negatywną grupą kontrolną. Wszystkie dawki obniżały też istotnie poziom kreatyny, kwasu moczowego i mocznika. Uzyskane wyniki zostały potwierdzone przez badanie histopatologiczne. Dawka LD50 była wyższa niż 2000 mg/kg, przygotowana mieszanka ma zatem silne działanie przeciwkamicowe i jest bezpieczna w użyciu.

Słowa kluczowe

EN

herb; herbal mixture; Tribulus terrestris; Boerhavia diffusa; punarnava; red spiderling zob.punarnava; spreading hogweed zob.punarnava; tarvine zob.punarnava; Azadirachta indica; antiurolithiatic activity; herbal medicine

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2015
• Tom: 61
• Numer: 2
• Opis fizyczny: p.41-49,fig.,ref.

Twórcy

autor

Saxena N.

• Rajeev Gandhi College of Pharmacy, Bhopal, Madhya Pradesh, India-462042

autor

Argal A.

• Rajeev Gandhi College of Pharmacy, Bhopal, Madhya Pradesh, India-462042

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Identyfikatory

DOI

10.1515/hepo-2015-0014